Cytochrome P450 2C11 in rats was recently found to metabolize diclofenac into a highly
reactive product that covalently bound to this enzyme before it could diffuse away and react with …

The nonsteroidal anti-inflammatory drug diclofenac causes a rare but potentially fatal
hepatotoxicity that may be associated with the formation of reactive metabolites. In this study, three …

Raloxifene is a selective estrogen receptor modulator which is effective in the treatment of
osteoporosis in postmenopausal women. We report herein that cytochrome P450 (P450)3A4 …

Montelukast sodium [1-{[(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl}cyclopropylacetic
acid sodium salt] (MK-476, …

… 3 ) exhibited high levels of covalent binding in both rat and human liver microsomes (Doss
et al., Citation2005). The binding was attenuated by GSH, but a search for typical GSH …

The metabolism of diclofenac has been reported to produce reactive benzoquinone imine
intermediates. We describe the identification of mercapturic acid derivatives of diclofenac in …

Molecular modeling was used to design a rigid analog of sitagliptin 1. The X-ray crystal
structure of sitagliptin bound to DPP-4 suggested that the central β-amino butyl amide moiety …

A series of β-aminoacylpiperidines bearing various fused five-membered heterocyclic rings
was synthesized as dipeptidyl peptidase IV inhibitors. Potent and relatively selective …

The in vitro metabolism of DuP 753, a novel nonpeptide angiotensin II receptor antagonist,
has been investigated in incubations with liver slice preparations from rats, monkeys and …

Objective To compare dexmedetomidine–midazolam with alfaxalone–midazolam for
sedation in leopard geckos (Eublepharis macularius). Study design Prospective, randomized, …