Direct Diffusion of cis-Diamminedichloroplatinum(II) in Intraperitoneal Rat Tumors after Intraperitonal Chemotherapy: A Comparison with Systemic Chemotherapy
G Los, PHA Mutsaers, WJF van der Vijgh, GS Baldew… - Cancer research, 1989 - AACR
Chemotherapy ip is increasingly being tested as a treatment modality for cancer limited to
the peritoneal cavity. We have developed a rat tumor model in which penetration and …
the peritoneal cavity. We have developed a rat tumor model in which penetration and …
Platinum distribution inintraperitoneal tumors afterintraperitoneal cisplatin treatment
G Los, PHA Mutsaers, WJM Lenglet, GS Baldew… - Cancer chemotherapy …, 1990 - Springer
… On the other hand, PIXE is a technique frequently applied in the biomedical field to detect
trace elements on a micro scale at concentration levels of about 1 lxg/g, with a spatial …
trace elements on a micro scale at concentration levels of about 1 lxg/g, with a spatial …
Selenium-induced Protection against cis-Diamminedichloroplatinum(II) Nephrotoxicity in Mice and Rats
GS Baldew, CJA van den Hamer, G Los… - Cancer Research, 1989 - AACR
… The mice were 8 wk of age and weighed 18 to 20 g at the start of the experiments. The rats
were used at an age of 8 to 9 wk and a weight of 240 to 260 g. All animals were provided with …
were used at an age of 8 to 9 wk and a weight of 240 to 260 g. All animals were provided with …
Selective Reduction of cis-Diamminedichloroplatinum(II) Nephrotoxicity by Ebselen
GS Baldew, JG McVie, MA van der Valk, G Los… - Cancer Research, 1990 - AACR
… The mice were 8 wk of age and weighed 18 to 20 g at the start of the experiment. All animals
were provided with standard laboratory food (SRMA chow; Hope Farms, Woerden, The …
were provided with standard laboratory food (SRMA chow; Hope Farms, Woerden, The …
The role of lipid peroxidation in the nephrotoxicity of cisplatin
NPE Vermeulen, GS Baldew - Biochemical pharmacology, 1992 - Elsevier
… [g, 91 have suggested that cisplatin exerts its nephrotoxic effects by the generation of free
radicals, which may cause oxidative damage in the kidney. McGinness et al. [lo] have shown …
radicals, which may cause oxidative damage in the kidney. McGinness et al. [lo] have shown …
The mechanism of interaction between cisplatin and selenite
GS Baldew, JGJ Mol, FJJ de Kanter, B Van Baar… - Biochemical …, 1991 - Elsevier
… The mice were 8 weeks of age and weighed 18-20 g at the start of the experiments. All
animals were provided with standard laboratory food (SRMA chow, Hope … GS BALDEW el al. …
animals were provided with standard laboratory food (SRMA chow, Hope … GS BALDEW el al. …
[PDF][PDF] Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds.
NP Vermeulen, GS Baldew, G Los, JG McVie… - Drug metabolism and …, 1993 - Citeseer
Administration of sodium selenite(NaSeO) 1 hr before cis-diam-minedichloroplatinum (ll)(referred
to herein as cisplatin) can protect against the nephrotoxicfty of cisplatin. The …
to herein as cisplatin) can protect against the nephrotoxicfty of cisplatin. The …
Cisplatin-induced changes of selenium levels and glutathione peroxidase activities in blood of testis tumor patients
…, JJM De Goeij, C Zegers, M De Vries, GS Baldew… - Cancer letters, 1988 - Elsevier
Haematocrit and glutathione peroxidase activity in blood, as well as selenium levels in blood,
erythrocytes and plasma, were determined in 15 patients during four courses of cisplatin …
erythrocytes and plasma, were determined in 15 patients during four courses of cisplatin …
The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells
GS Baldew, AP Boymans, JGJ Mol… - Biochemical …, 1992 - Elsevier
… Baldew GS, Volkers KJ and van den Hamer CIA, Reduction of cisplatin nephrotoxicity by …
These data indicate that alveolar macrophages are capable of secreting L-as-g-derived …
These data indicate that alveolar macrophages are capable of secreting L-as-g-derived …
Determination of cisplatin and related platinum complexes in plasma ultrafiltrate and urine by high-performance liquid chromatography with on-line radioactivity …
GS Baldew, KJ Volkers, JJM De Goeij… - … of Chromatography B …, 1989 - Elsevier
A reversed-phase ion-pair chromatographic method with on-line radioactivity detection for the
simultaneous determination of 195m Pt-labelled cisplatin and related platinum complexes …
simultaneous determination of 195m Pt-labelled cisplatin and related platinum complexes …