Incorporation of 6-thioguanine into nucleic acids

GA LePage - Cancer Research, 1960 - AACR
A method was devised by which 6-thioguanine-8-C 14 can be synthesized on a small scale
in a 63 per cent yield. The product was used to establish that Ehrlich ascites cells …

Biological energy transformations during shock as shown by tissue analyses

GA LePage - American Journal of Physiology-Legacy …, 1946 - journals.physiology.org
NOBLE-COLLIP SHOCK. The theoretical aspects of the metabolic events associated with
the shock syndrome have been discussed in the preceding paper (1). Students of cellular …

Basic biochemical effects and mechanism of action of 6-thioguanine

GA LePage - Cancer research, 1963 - AACR
… has been reported by LePage and Jones (7). It was established … LEPAGE,GA, and JONES,M.
Purinethiols as Feedback Inhibitors of Purine Synthesis in Ascites Tumor Cells. Cancer Res.…

The nutrition of tumors; a review.

JF Henderson, GA LePage - Cancer Research, 1959 - cabdirect.org
The nutrition of tumors ; a review. Cookies on CAB Direct Like most websites we use cookies.
This is to ensure that we give you the best experience possible. Continuing to use www.cabdirect.org …

In Vitro Incorporation of Glycine-2-C14 into Purines and Proteins

GA LePage - Cancer Research, 1953 - AACR
In vitro experiments with whole-cell preparations of Ehrlich carcinoma, Gardner lymphosarcoma,
and mouse liver led to extensive incorporation of glycine-2-C 14 into the cell proteins …

Improved antitumor effects in 3'-branched homologs of 2'-deoxythioguanine. Synthesis and evaluation of thioguanine nucleosides of 2, 3-dideoxy-3-(hydroxymethyl)-D …

…, DW Henry, CE Cass, GA LePage - Journal of Medicinal …, 1979 - ACS Publications
The 3-(hydroxymethyl) branched homologue of 2-deoxyribofuranose was synthesized from
the corresponding branched ribofuranose 2-Q-(S-methyl dithiocarbonate) with tributyltin …

Intracellular Distribution of Radioactivity in Nucleic Acid Nucleotides and Proteins Following Simultaneous Administration of P32 and Glycine-2-C14

EP Tyner, C Heidelberger, GA LePage - Cancer Research, 1953 - AACR
… with the in vitro work of LePage (3@),who has studied nucleic acid purine synthesis in
Ehnlich … LEPAGE,GA In Vitro Incorporation of Glycine-2-C'4 into Purines and Proteins. Cancer …

Enhancement of the antitumor activity of arabinofuranosyladenine by 2′-deoxycoformycin

GA LePage, LS Worth, AP Kimball - Cancer Research, 1976 - AACR
The 6C3HED lymphosarcoma, a tumor cell line very sensitive to 9-β-d-arabinofuranosyladenine
(ara-A), and 6C3HED/ara-A, a line resistant to ara-A, were studied. Both were …

Metabolic Effects of 9-d-Arabinosylpurines in Ascites Tumor Cells

JJ Brink, GA LePage - Cancer Research, 1964 - AACR
Spongoadenosine (9-β-d-arabinofuranosyladenine) was found to inhibit the growth of TA3
and 6C3HED ascites tumors. The growth of L1210 tumors was only slightly affected. Mice …

[PDF][PDF] Studies of 9-β-D-arabinofuranosyladenine in man

GA LePage, A KHALIQ, JA Gottlieb - Drug Metabolism and Disposition, 1973 - Citeseer
Materials and Methods Informed consent was obtained from all patients involved in the study.
Ara-A was supplied by Parke, Davis and Co., through Drug Research and Development, …