Primary hepatocytes and their cultures are a simple but versatile, well-controlled, and
relatively easy to handle in vitro system that is well-accepted for investigating xenobiotic …

Modulation of chromatin structure through histone acetylation / deacetylation is known to be
one of the major mechanisms involved in the regulation of gene expression. Two opposing …

This is the 54th report of a series of workshops organised by the European Centre for the
Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 …

Protein acetylation, catalyzed by the opposing activities of histone deacetylases (HDAC) and
histone acetyltransferases, is now recognized to be an important epigenetic modulator of …

In vitro models, based on liver cells or tissues, are indispensable in the early preclinical phase
of drug development. An important breakthrough in establishing cell models has been the …

We examine the likely drivers of intraday momentum, defined as a significantly positive
relation between the first half-hour and the last half-hour return, in a foreign exchange market …

Histone deacetylase (HDAC) inhibitors target key steps of tumor development: They inhibit
proliferation, induce differentiation and/or apoptosis, and exhibit potent antimetastatic and …

Background/Aims: The effects of Trichostatin A (TSA), a drug candidate for cancer therapy,
on proliferation and survival of primary hepatocytes, the major site of xenobiotic …

Phase I biotransformation of Trichostatin A (TSA), a histone deacetylase inhibitor with
promising antifibrotic and antitumoral properties, was investigated in rat and human liver …

… Male outbred Sprague-Dawley rats (200–300 g) were purchased from Charles River …
Depauw G. for their dedicated technical assistance. Also appreciation is expressed to Mrs. …