[BOOK][B] Introduction to drug metabolism
GG Gibson, P Skett - 2013 - books.google.com
This introduction to the mechanisms by which the body metabolizes and excretes
administered drugs is directed at advanced undergraduate biochemists, pharmacologists …
administered drugs is directed at advanced undergraduate biochemists, pharmacologists …
The effect of peroxisome prouferators on microsomal. Peroxisomal, and mitochondrial enzyme activities in the liver and kidney
…, WE Jones, FW Bonner, GG Gibson - Drug Metabolism …, 1987 - Taylor & Francis
Peroxisome proliferators are a group of structurally diverse chemicals which on
administration to rodents cause an increase in peroxisome number and a decrease in plasma …
administration to rodents cause an increase in peroxisome number and a decrease in plasma …
Comparative aspects of the mammalian cytochrome P450 IV gene family
G Gordon Gibson - Xenobiotica, 1989 - Taylor & Francis
1. The structures of mammalian cytochrome P-450 isoenzymes have been compared with
respect to micro-sequence heterogeneity and their haem-binding cysteinyl peptides. 2. …
respect to micro-sequence heterogeneity and their haem-binding cysteinyl peptides. 2. …
Evaluation of the toxicological relevance of CYP3A4 induction.
NJ Plant, GG Gibson - Current opinion in drug discovery & …, 2003 - europepmc.org
CYP3A4 is the most abundant cytochrome P450 in human liver, comprising approximately
30% of the total liver P450 content. This enzyme has an important role in endogenous …
30% of the total liver P450 content. This enzyme has an important role in endogenous …
Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers
W El-Sankary, GG Gibson, A Ayrton, N Plant - Drug Metabolism and …, 2001 - ASPET
Regulation of the CYP3A4 gene has been studied using an in vitro reporter gene assay. The
effect of 17 xenobiotics on ∼1 kilobase of the CYP3A4 proximal promoter, upstream of a …
effect of 17 xenobiotics on ∼1 kilobase of the CYP3A4 proximal promoter, upstream of a …
Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of …
GG Gibson, TC Orton, PP Tamburini - Biochemical Journal, 1982 - portlandpress.com
Hypolipidaemic drugs induce peroxisomal proliferation in the liver and many induce the
formation of the hepatic endoplasmic reticulum in general and the formation of cytochrome P-…
formation of the hepatic endoplasmic reticulum in general and the formation of cytochrome P-…
Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors
W El-Sankary, NJ Plant, GG Gibson, DJ Moore - Drug Metabolism and …, 2000 - ASPET
The molecular mechanisms of regulation of theCYP3A4 gene have been examined in an in
vitro reporter gene system, containing −1 kb of the CYP3A4 promoter, in a HepG2 cell line. …
vitro reporter gene system, containing −1 kb of the CYP3A4 promoter, in a HepG2 cell line. …
Multiple forms of hepatic cytochrome P‐450: Purification, characterisation and comparison of a novel clofibrate‐induced isozyme with other major forms of cytochrome …
…, RJ Makowski, B Morris, GG Gibson - European journal of …, 1984 - Wiley Online Library
In the present studies, a novel form of highly purified cytochrome P‐450 (cytochrome P‐452)
isolated from the hepatic microsomes of clofibrate‐pretreated rats has been compared to …
isolated from the hepatic microsomes of clofibrate‐pretreated rats has been compared to …
Pathways of drug metabolism
GG Gibson, P Skett, GG Gibson, P Skett - Introduction to drug metabolism, 1994 - Springer
The routes by which drugs may be metabolised or biotransformed are many and varied and
include the chemical reactions of oxidation, reduction, hydrolysis, hydration, conjugation and …
include the chemical reactions of oxidation, reduction, hydrolysis, hydration, conjugation and …
Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element
W El-Sankary, V Bombail, GG Gibson, N Plant - Drug metabolism and …, 2002 - ASPET
CYP3A4 is the most abundant cytochrome P450 (P450) in human liver, comprising
approximately 30% of the total liver P450 content. This enzyme has an important role in steroid …
approximately 30% of the total liver P450 content. This enzyme has an important role in steroid …