Which human metabolites have we MIST? Retrospective analysis, practical aspects, and perspectives for metabolite identification and quantification in pharmaceutical …
L Leclercq, F Cuyckens, GSJ Mannens… - Chemical research in …, 2009 - ACS Publications
With the recent publication of the FDA guidance on metabolites in safety testing (MIST), a
reflection is provided that describes the impact of this guidance on the processes of drug …
reflection is provided that describes the impact of this guidance on the processes of drug …
The metabolism and excretion of galantamine in rats, dogs, and humans
GSJ Mannens, CAW Snel, J Hendrickx… - Drug metabolism and …, 2002 - ASPET
Galantamine is a competitive acetylcholine esterase inhibitor with a beneficial therapeutic
effect in patients with Alzheimer's disease. The metabolism and excretion of orally …
effect in patients with Alzheimer's disease. The metabolism and excretion of orally …
The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1, 2-ethanediol,[1-2-chlorophenyl]-, 2-carbamate,[S]-) in humans
GSJ Mannens, J Hendrickx, CGM Janssen… - Drug metabolism and …, 2007 - ASPET
RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-; CAS Registry Number
194085-75-1) is a novel neuromodulator in clinical development for the treatment of epilepsy…
194085-75-1) is a novel neuromodulator in clinical development for the treatment of epilepsy…
Rapid permeability screening in drug discovery to predict human intestinal absorption
GSJ Mannens, H Bohets, P Verboven… - … Challenges in Drug …, 2002 - Springer
After oral administration of a drug, several hurdles have to be passed before the drug becomes
systemically available. First of all, the drug has to be liberated from the pharmaceutical …
systemically available. First of all, the drug has to be liberated from the pharmaceutical …
[CITATION][C] Partial purification and HPLC activity determination of chicken liver acetylcoenzyme A: glucosamine N-acetyltransferase
GSJ MANNENS, GAS SLEGERS - Chimica oggi, 1990 - pascal-francis.inist.fr
… Author MANNENS, GS J; SLEGERS, GA S …
Absorption, metabolism, and excretion of darunavir, a new protease inhibitor, administered alone and with low-dose ritonavir in healthy subjects
M Vermeir, S Lachau-Durand, G Mannens… - Drug Metabolism and …, 2009 - ASPET
Absorption, metabolism, and excretion of darunavir, an inhibitor of human immunodeficiency
virus protease, was studied in eight healthy male subjects after a single oral dose of 400 …
virus protease, was studied in eight healthy male subjects after a single oral dose of 400 …
Total grain size distribution of a mafic subplinian tephra, TB-2, from the 1986 Izu-Oshima eruption, Japan: An estimation based on a theoretical model of tephra …
K Mannen - Journal of Volcanology and Geothermal Research, 2006 - Elsevier
Total grain size distribution was estimated using field data and theoretical modelling. Isopleth
maps of each size were constructed at intervals of 1 phi based on the detailed sampling …
maps of each size were constructed at intervals of 1 phi based on the detailed sampling …
[CITATION][C] Identification of cytochrome P450 (CYP450) enzymes responsible for the metabolism of TMC114, a new protease inhibitor, in human liver microsomes …
R Mamidi, GSJ Mannens, J Hendrickx, M Vermeir… - Annual meeting of the …, 2005
[CITATION][C] Which metabolites have we MIST? Retrospective analysis, practical aspects and perspectives for metabolite identification and quantification in …
L Leclerq, F Cuyckens, GSJ Mannens, R de Vries… - Chem. Res. Toxicol, 2009
[CITATION][C] FROM THE LABORATORY OF ANALYTICAL CHEMISTRY AND THE INSTITUTE OF NUCLEAR SCIENCES, STATE UNIVERSITY OF GENT, BELGIUM.
GSJ MANNENS, G SLEGERS, P GOETHALS… - Acta Radiologica …, 1991