Models and approaches describing the metabolism, transport, and toxicity of drugs administered by the ocular route
…, M Walles, V Sasseville, M Gunduz, GR Iyer… - Drug metabolism and …, 2018 - ASPET
The eye is a complex organ with a series of anatomic barriers that provide protection from
physical and chemical injury while maintaining homeostasis and function. The physiology of …
physical and chemical injury while maintaining homeostasis and function. The physiology of …
Pharmacokinetics and safety of galantamine in subjects with hepatic impairment and healthy volunteers
Q Zhao, GR Iyer, T Verhaeghe… - The Journal of Clinical …, 2002 - Wiley Online Library
The objective of this study was to compare the pharmacokinetics and safety of galantamine
in subjects with hepatic impairment with those in healthy subjects. This was an open‐label …
in subjects with hepatic impairment with those in healthy subjects. This was an open‐label …
Application of a first-pass effect model to characterize the pharmacokinetic disposition of venlafaxine after oral administration to human subjects
DR Taft, GR Iyer, L Behar, RV Digregorio - Drug metabolism and disposition, 1997 - ASPET
Venlafaxine (VEN), a drug used in the treatment of depression, undergoes significant first-pass
metabolism after oral dosing toO-desmethylvenlafaxine (ODV), a metabolite with …
metabolism after oral dosing toO-desmethylvenlafaxine (ODV), a metabolite with …
Effects of PRX-00023, a novel, selective serotonin 1A receptor agonist on measures of anxiety and depression in generalized anxiety disorder: results of a double …
…, SR Donahue, M Kauffman, GR Iyer… - Journal of clinical …, 2008 - journals.lww.com
PRX-00023, a serotonin 1A receptor agonist, was designed to provide high potency and
selectivity for its target. To assess the possible therapeutic utility in anxiety, a randomized, …
selectivity for its target. To assess the possible therapeutic utility in anxiety, a randomized, …
Comparison of low Reynolds number k–ε models in simulation of momentum and heat transport under high free stream turbulence
GR Iyer, S Yavuzkurt - International journal of heat and mass transfer, 1999 - Elsevier
Calculations of the effects of high free stream turbulence (FST) on the transport of momentum
and heat in a flat plate turbulent boundary layer are presented. Four well known low …
and heat in a flat plate turbulent boundary layer are presented. Four well known low …
Pharmacokinetics and safety of olopatadine hydrochloride 0.77% in healthy subjects with asymptomatic eyes: data from 2 independent clinical studies
E Meier, A Narvekar, GR Iyer, HB DuBiner… - Clinical …, 2017 - Taylor & Francis
Purpose To assess the pharmacokinetics and safety of hydrochloride ophthalmic solution
0.77% olopatadine from 2 independent (Phase I and Phase III, respectively) clinical studies in …
0.77% olopatadine from 2 independent (Phase I and Phase III, respectively) clinical studies in …
Ocular pharmacokinetics comparison between 0.2% olopatadine and 0.77% olopatadine hydrochloride ophthalmic solutions administered to male New Zealand white …
GR Iyer, MM Cason, SW Womble, G Li… - Journal of Ocular …, 2015 - liebertpub.com
Purpose: The primary objective of this study was to compare uptake and distribution of the
commercially available formulation of 0.2% olopatadine and the newly developed 0.77% …
commercially available formulation of 0.2% olopatadine and the newly developed 0.77% …
Population analysis of the pharmacokinetics and pharmacodynamics of RWJ-270201 (BCX-1812) in treating experimental influenza A and B virus in healthy …
GR Iyer, S Liao, J Massarella - Aaps Pharmsci, 2002 - Springer
Objective Our objective was to assess the pharmacokinetics and pharmacodynamics of RWJ-270201
(BCX-1812), an oral neuraminidase inibitor for the treatment of influenza A and B …
(BCX-1812), an oral neuraminidase inibitor for the treatment of influenza A and B …
Tolerability, pharmacokinetics, and neuroendocrine effects of PRX‐00023, a novel 5‐HT1A agonist, in healthy subjects
GR Iyer, JFR Jr, S Oshana, M Kauffman… - The Journal of …, 2007 - Wiley Online Library
PRX‐00023 is a novel, nonazapirone 5‐HT1A agonist in clinical development for treatment
of affective disorders. The objectives of the initial clinical phase I studies (a single ascending …
of affective disorders. The objectives of the initial clinical phase I studies (a single ascending …
In Vitro Characterization of the Erythrocyte Distribution of Methazolamide: A Model of Erythrocyte Transport and Binding Kinetics
GR Iyer, RA Bellantone, DR Taft - Journal of pharmacokinetics and …, 1999 - Springer
The rate and extent of binding of methazolamide to human erythrocytes was studied in vitro.
All experiments were carried out at physiological temperature (37C) and pH (7.4). …
All experiments were carried out at physiological temperature (37C) and pH (7.4). …