Purpose. The objective of this study was to determine the expression and activity of multidrug
resistance–associated protein (MRP) in the retinal pigment epithelial (RPE) cells and to …

Sacubitril/valsartan (LCZ696) is indicated for the treatment of heart failure with reduced
ejection fraction. Absorption of sacubitril/valsartan and conversion of sacubitril (prodrug) to …

Context Glucocorticoids (GCs) prescribed for chronic pediatric illnesses are associated with
osteoporotic fractures. Objective This study aims to determine the efficacy and safety of …

Epithelial and/or endothelial cells sealed by tight junctions serve as the major membrane
barriers for the transport of nutrients, ions, and drugs into intraocular tissues. The principal …

Purpose LCZ696 (sacubitril/valsartan), an angiotensin receptor neprilysin inhibitor, is indicated
for chronic heart failure (HF) and reduced ejection fraction (HFrEF) to reduce the risk of …

Omadacycline is a first-in-class aminomethylcycline antibiotic with microbiological activity
against Gram-positive and Gram-negative aerobes and anaerobes and atypical bacteria that is …

The characterization of the pharmacokinetic (PK) and pharmacodynamic (PD) properties in
pediatric patients is essential in supporting the recommended dosage of canakinumab in the …

LCZ696, a novel angiotensin receptor neprilysin inhibitor, is in development for the treatment
of heart failure. Administration of LCZ696 results in systemic exposure to sacubitril (inactive …

The artemether-lumefantrine combination requires food intake for the optimal absorption of
lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid …

Background: Vildagliptin is an orally active, potent and selective inhibitor of dipeptidyl
peptidase IV (DPP-4), the enzyme responsible for the degradation of incretin hormones. By …