The localization of substance P in brain regions that coordinate stress responses and receive
convergent monoaminergic innervation suggested that substance P antagonists might …

OBJECTIVE Oxyntomodulin (OXM) is a glucagon-like peptide 1 (GLP-1) receptor (GLP1R)/glucagon
receptor (GCGR) dual agonist peptide that reduces body weight in obese subjects …

Structural modifications requiring novel synthetic chemistry were made to the morpholine
acetal human neurokinin-1 (hNK-1) receptor antagonist 4, and this resulted in the discovery of 2…

Hemokinin-1 (HK-1) is a novel substance P (SP)-like peptide that is encoded by the
preprotachykinin C (PPT-C) gene recently identified in mouse B cells and shown to be a potentially …

Oxyntomodulin (OXM) is a peptide secreted postprandially from the L‐cells of the gut that
has a weak affinity for both the glucagon‐like peptide‐1 receptor (GLP1R) and the glucagon …

The regioselective dibenzylphosphorylation of 2 followed by catalytic reduction in the
presence of N-methyl-d-glucamine afforded 2-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(…

We have identified a series of potent, orally bioavailable, non-peptidyl, triarylimidazole and
triarylpyrrole glucagon receptor antagonists. 2-(4-Pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-…

… The cleared supernatant was mixed with 10 g of Bio-Rex 70 equilibrated in 1% succinic
acid, pH 4.8. After being stirred for 3 h at 4 C, the resin was poured into a 2.5-cm column …

Glucagon-like peptide-1 (GLP-1) and oxyntomodulin (OXM) are peptide hormones secreted
postprandially from the gut that stimulate insulin secretion in a glucose-dependent manner. …

… Cooper a , Gary G. Chicchi c , Kevin Dinnell a , Jason M. Elliott a , Gregory J.
Hollingworth a , Marc M. … Compounds 1f and 1h–k were made using a resin-bound …