Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
Background: Pharmacokinetic studies have shown that the small intestine is the major site of
absorption for many flavonoid glucosides. Flavonoids are generally present as glycosylated …
absorption for many flavonoid glucosides. Flavonoids are generally present as glycosylated …
Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
Lactase phlorizin hydrolase (LPH; EC 3.2.1.62) is a membrane‐bound, family 1 β‐glycosidase
found on the brush border of the mammalian small intestine. LPH, purified from sheep …
found on the brush border of the mammalian small intestine. LPH, purified from sheep …
Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo
…, B Holst, FA Mellon, Y Bao, GW Plumb… - Drug Metabolism and …, 2003 - ASPET
For the first time the human intestinal effective permeability, estimated from the luminal
disappearance and intestinal metabolism of phytochemicals, sulforaphane and quercetin-3,4′-…
disappearance and intestinal metabolism of phytochemicals, sulforaphane and quercetin-3,4′-…
Metabolism of chlorogenic acid by human plasma, liver, intestine and gut microflora
GW Plumb, MT Garcia‐Conesa… - Journal of the …, 1999 - Wiley Online Library
Extracts of human small intestine epithelium, liver, plasma and colonic microflora (as a faecal
sample) were prepared and esterase activity determined by incubation with chlorogenic …
sample) were prepared and esterase activity determined by incubation with chlorogenic …
Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells
G Williamson, GW Plumb, Y Uda, KR Price… - …, 1996 - academic.oup.com
It has recently been shown by Hollman et al. (Am. J. Clin. Nutr., 62, 1276–1282) that flavonoid
glycosides are preferentially absorbed from dietary onions compared to the flavonoid …
glycosides are preferentially absorbed from dietary onions compared to the flavonoid …
Antioxidant properties of the major polyphenolic compounds in broccoli
GW Plumb, KR Price, MJC Modes… - Free Radical …, 1997 - Taylor & Francis
We have examined the antioxidant activity of the major phenolic compounds in Broccoli: two
flavonol glycosides (quercetin 3–O-sophoroside and kaemp-ferol 3-O-sophoroside) and …
flavonol glycosides (quercetin 3–O-sophoroside and kaemp-ferol 3-O-sophoroside) and …
Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin
…, G Williamson, P Needs, GW Plumb - Free radical …, 2004 - Taylor & Francis
Quercetin is an important dietary flavonoid with in vitro antioxidant activity. However, it is
found in human plasma as conjugates with glucuronic acid, sulfate or methyl groups, with no …
found in human plasma as conjugates with glucuronic acid, sulfate or methyl groups, with no …
[HTML][HTML] Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway
JM Gee, MS DuPont, AJ Day, GW Plumb… - The Journal of …, 2000 - Elsevier
Flavonoids are polyphenolic plant secondary metabolites with antioxidant and other
biological activities potentially beneficial to health. Food-borne flavonoids occur mainly as …
biological activities potentially beneficial to health. Food-borne flavonoids occur mainly as …
Antioxidant properties of catechins and proanthocyanidins: Effect of polymerisation, galloylation and glycosylation
GW Plumb, S De Pascual-Teresa… - Free radical …, 1998 - Taylor & Francis
A range of catechins and oligomeric procyanidins was purified by high performance liquid
chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, …
chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, …
Antioxidant properties of flavonol glycosides from green beans
GW Plumb, KR Price, G Williamson - Redox Report, 1999 - Taylor & Francis
We have examined the antioxidant activity of one class of polyphenolic compounds in green
beans: two novel flavonol glycosides (quercetin 3-O-[xylosyl(1→ 2)]-rhamnosyl (1→6)-…
beans: two novel flavonol glycosides (quercetin 3-O-[xylosyl(1→ 2)]-rhamnosyl (1→6)-…