Effective treatments for primary brain tumors and brain metastases represent a major unmet
medical need. Targeting the CDK4/CDK6-cyclin D1-Rb-p16/ink4a pathway using a potent …

It has been shown both in vivo and in culture that astrocytes communicate with brain microvessel
endothelial cells (BMECs) to induce many of the blood—brain barrier characteristics …

Thiazolidinediones may slow the progression of type 2 diabetes by preserving pancreatic β-cells.
The effects of pioglitazone (PIO) on structure and function of β-cells in KKA(y), C57BL/…

In silico tools are regularly utilized for designing and prioritizing compounds to address
challenges related to drug metabolism and pharmacokinetics (DMPK) during the process of drug …

Cyclic peptide (CP) natural products provide useful model systems for mapping “beyond-Rule-of-5”
(bRo5) space. We identified the phepropeptins as natural product CPs with potential …

We examined a series of selenorhodamines with amide and thioamide functionality at the 5-position
of a 9-(2-thienyl) substituent on the selenorhodamine core for their potential as …

Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has
been revealed recently. To investigate comprehensively the potential role of Bcrp at the …

We have examined 46 tetramethylrosamine/rhodamine derivatives with structural diversity in
the heteroatom of the xanthylium core, the amino substituents of the 3- and 6-positions, and …

Background The United States faces a national crisis involving opioid medications, where
currently more than 130 people die every day. To combat this epidemic, a better …

Oxidative stress is considered a cause or propagator of acute and chronic disorders of the
central nervous system. Novel 2,4-diamino-pyrrolo[2,3-d]pyrimidines are potent inhibitors of …