User profiles for Grace L Guo

Grace L. Guo

Rutgers University
Verified email at eohsi.rutgers.edu
Cited by 11574

International patterns and trends in thyroid cancer incidence, 1973–2002

…, A Sjodin, Y Zhang, Y Bai, C Zhu, GL Guo… - Cancer causes & …, 2009 - Springer
During the past several decades, an increasing incidence of thyroid cancer has been reported
in many parts of the world. To date, no study has compared the trends in thyroid cancer …

[HTML][HTML] Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

I Kim, SH Ahn, T Inagaki, M Choi, S Ito, GL Guo… - Journal of lipid …, 2007 - ASBMB
Bile acid concentrations are controlled by a feedback regulatory pathway whereby activation
of the farnesoid X receptor (FXR) represses transcription of both the CYP7A1 gene, …

[PDF][PDF] Mechanism of tissue‐specific farnesoid X receptor in suppressing the expression of genes in bile‐acid synthesis in mice

…, JYL Chiang, Y Zhang, CD Klaassen, GL Guo - …, 2012 - Wiley Online Library
Activation of farnesoid X receptor (Fxr, Nr1h4) is a major mechanism in suppressing bile‐acid
synthesis by reducing the expression levels of genes encoding key bile‐acid synthetic …

[HTML][HTML] Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

GL Guo, G Lambert, M Negishi, JM Ward… - Journal of Biological …, 2003 - ASBMB
The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are
important in maintaining bile acid homeostasis. Deletion of both FXR and PXR in vivo by cross-…

NF-E2-related factor 2 inhibits lipid accumulation and oxidative stress in mice fed a high-fat diet

…, RL Yeager, MA Gyamfi, N Esterly, GL Guo… - … of Pharmacology and …, 2008 - ASPET
NF-E2-related factor 2 (Nrf2) is a transcription factor that is activated by oxidative stress and
electrophiles that regulates the expression of numerous detoxifying and antioxidant genes. …

Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice

…, D Silbert, O Tsybrovskyy, K Zatloukal, GL Guo… - Gastroenterology, 2003 - Elsevier
Background & Aims : Cholestasis induces changes in hepatic adenosine triphosphate-binding
cassette (ABC) transporter expression. We aimed to investigate the role of the nuclear …

Farnesoid X receptor deficiency in mice leads to increased intestinal epithelial cell proliferation and tumor development

…, Y Zhang, V Ganapathy, FJ Gonzalez, GL Guo - … of Pharmacology and …, 2009 - ASPET
Increased dietary fat consumption is associated with colon cancer development. The exact
mechanism by which fat induces colon cancer is not clear, however, increased bile acid …

Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet

B Kong, JP Luyendyk, O Tawfik, GL Guo - Journal of Pharmacology and …, 2009 - ASPET
Nonalcoholic steatohepatitis (NASH) comprises dysregulation of lipid metabolism and
inflammation. Identification of the various genetic and environmental susceptibility factors for …

[PDF][PDF] Genome‐wide tissue‐specific farnesoid X receptor binding in mouse liver and intestine

…, SN Hart, B Kong, J Fang, X Zhong, GL Guo - …, 2010 - Wiley Online Library
Farnesoid X receptor (FXR) is a bile acid‐activated transcription factor belonging to the
nuclear receptor superfamily. FXR is highly expressed in liver and intestine and crosstalk …

[HTML][HTML] Bile acids and FXR: novel targets for liver diseases

M Stofan, GL Guo - Frontiers in medicine, 2020 - frontiersin.org
Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from cholesterol
and have been shown to be essential for lipid homeostasis. BAs regulate a variety of …