Physiological content and intrinsic activities of 10 cytochrome P450 isoforms in human normal liver microsomes
…, Q Wen, J Gao, YJ Zhang, XH Qian, HL Qiao - … of Pharmacology and …, 2016 - ASPET
Due to a lack of physiologic cytochrome P450 (P450) isoform content, P450 activity is typically
only determined at the microsomal level (per milligram of microsomal protein) and not at …
only determined at the microsomal level (per milligram of microsomal protein) and not at …
[HTML][HTML] Significant change of cytochrome P450s activities in patients with hepatocellular carcinoma
…, Y Fang, J Gao, MZ Cui, XP He, LJ Jia, H Jin, HL Qiao - Oncotarget, 2016 - ncbi.nlm.nih.gov
The lack of information concerning individual variation in drug-metabolizing enzymes is one
of the most important obstacles for designing personalized medicine approaches for …
of the most important obstacles for designing personalized medicine approaches for …
Pharmacokinetics of three proton pump inhibitors in Chinese subjects in relation to the CYP2C19 genotype
HL Qiao, YR Hu, X Tian, LJ Jia, N Gao… - European journal of …, 2006 - Springer
Objective Omeprazole, lansoprazole and rabeprazole have been widely used as proton
pump inhibitors (PPIs). They can be metabolized in the liver by CYP2C19, a polymorphic …
pump inhibitors (PPIs). They can be metabolized in the liver by CYP2C19, a polymorphic …
Synthesis and biological activity of n-butylphthalide derivatives
W Wang, XX Cha, J Reiner, Y Gao, HL Qiao… - European journal of …, 2010 - Elsevier
A series of n-butylphthalide derivatives were designed and synthesized. The in vitro
activities of these compounds were evaluated by a resting tension of isolated rat thoracic …
activities of these compounds were evaluated by a resting tension of isolated rat thoracic …
[HTML][HTML] Changes in cytochrome P450s-mediated drug clearance in patients with hepatocellular carcinoma in vitro and in vivo: a bottom-up approach
…, N Gao, X Tian, Y Fang, Q Wen, LJ Jia, H Jin, HL Qiao - Oncotarget, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) accompanied by severe liver dysfunction is a serious disease,
which results in altered hepatic clearance. Generally, maintenance doses depend upon …
which results in altered hepatic clearance. Generally, maintenance doses depend upon …
Correlation of cytochrome P450 oxidoreductase expression with the expression of 10 isoforms of cytochrome P450 in human liver
…, N Gao, X Tian, J Gao, Q Wen, LJ Jia, HL Qiao - Drug Metabolism and …, 2016 - ASPET
Human cytochrome P450 oxidoreductase (POR) provides electrons for all microsomal
cytochromes P450 (P450s) and plays an indispensable role in drug metabolism catalyzed by this …
cytochromes P450 (P450s) and plays an indispensable role in drug metabolism catalyzed by this …
Higher CYP2E1 activity correlates with hepatocarcinogenesis induced by diethylnitrosamine
…, Y Fang, YF Zhang, J Zhou, H Jin, HL Qiao - … of Pharmacology and …, 2018 - ASPET
Hepatocellular carcinoma (HCC) is one of the most common types of primary liver cancer and
the third most frequent cause of cancer death worldwide. Diethylnitrosamine (DEN) is one …
the third most frequent cause of cancer death worldwide. Diethylnitrosamine (DEN) is one …
[HTML][HTML] Inhibition of baicalin on metabolism of phenacetin, a probe of CYP1A2, in human liver microsomes and in rats
N Gao, B Qi, F Liu, Y Fang, J Zhou, L Jia, H Qiao - PloS one, 2014 - journals.plos.org
Baicalin has been used as mainly bioactive constituent of about 100 kinds of traditional
Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 …
Chinese medicines in Chinese pharmacopoeia. The effect of baicalin on cytochrome P450 …
Polymorphisms and haplotype analysis of IL-4Rα Q576R and I75V in patients with penicillin allergy
CZ Huang, J Yang, HL Qiao, LJ Jia - European journal of clinical …, 2009 - Springer
Background The interleukin (IL)-4 and IL-4R genes are linked to allergic diseases and atopy
and elevated serum IgE levels closely follow the presentation of penicillin allergy. We have …
and elevated serum IgE levels closely follow the presentation of penicillin allergy. We have …
[HTML][HTML] Inhibitory effects of baicalin on the expression and activity of CYP3A induce the pharmacokinetic changes of midazolam in rats
X Tian, ZY Cheng, H Jin, J Gao, HL Qiao - … Based Complementary and …, 2013 - hindawi.com
Baicalin, a flavonoid compound isolated from Scutellaria baicalensis, has been shown to
possess antiinflammatory, antiviral, antitumour, and immune regulatory properties. The present …
possess antiinflammatory, antiviral, antitumour, and immune regulatory properties. The present …