The blood–brain barrier (BBB) maintains brain homeostasis by controlling traffic of molecules
from the circulation into the brain. This function is predominantly dependent on proteins …

The blood–brain barrier ( BBB ) maintains brain homeostasis by tightly regulating the exchange
of molecules with systemic circulation. It consists primarily of microvascular endothelial …

Introduction: Drug-metabolizing enzymes and transporters play an important role in drug
absorption, distribution, metabolism and excretion and, consequently, they influence drug …

Many genetic and environmental factors lead to interindividual variations in the metabolism
and transport of drugs, profoundly affecting efficacy and toxicity. Precision dosing, that is, …

The quantification of drug-metabolizing enzymes and transporters is important for in vitro-in
vivo extrapolation (IVIVE) of xenobiotic clearance, which has become an integral part of drug …

In this report, we briefly review the application of Beynon and Gaskell's QconCAT methodology
to the quantification of a variety of proteomes. We then describe the development of two …

Liver enzymes and transporters play an essential role in xenobiotic metabolism, distribution
and elimination. Pre-clinical safety assessment relies on studies on animal models, …

Background: The quantification of tissue expression of drug transporters is important in
pharmacokinetic studies to understand the disposition of drugs and their metabolites and predict …

The quantification of cytochrome P450 (P450) and uridine 5'-diphospho-glucuronosyltransferase
(UGT) enzymes is important for in vitro-in vivo extrapolation (IVIVE) of xenobiotic …

… Yasmine Elmorsi, Hajar Al Feteisi, Brahim Achour, Zubida M. Al-Majdoub, Jill …
Performed data analysis: Elmorsi, Al Feteisi … proteins, and each has its advantages and …