User profiles for Hannah M. Jones
Hannah JonesCertara Inc. Verified email at certara.com Cited by 5405 |
[BOOK][B] An introduction to political geography: space, place and politics
… Jones 2010), the framing of ‘the war on terror’ (Coleman 2004; Dodds 2007; Hannah 2006)
and the justification and conduct of the interventions in Afghanistan and Iraq (Dalby 2009; …
and the justification and conduct of the interventions in Afghanistan and Iraq (Dalby 2009; …
A novel strategy for physiologically based predictions of human pharmacokinetics
Background The major aim of this study was to develop a strategy for predicting human
pharmacokinetics using physiologically based pharmacokinetic (PBPK) modelling. This was …
pharmacokinetics using physiologically based pharmacokinetic (PBPK) modelling. This was …
Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data
With efforts to reduce cytochrome P450-mediated clearance (CL) during the early stages of
drug discovery, transporter-mediated CL mechanisms are becoming more prevalent. …
drug discovery, transporter-mediated CL mechanisms are becoming more prevalent. …
PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the …
…, RDO Jones, HM Jones, CR Gibson, M Rowland… - Journal of …, 2011 - Elsevier
The objective of this study is to assess the effectiveness of physiologically based
pharmacokinetic (PBPK) models for simulating human plasma concentration–time profiles for the …
pharmacokinetic (PBPK) models for simulating human plasma concentration–time profiles for the …
Modelling and PBPK simulation in drug discovery
HM Jones, IB Gardner, KJ Watson - The AAPS journal, 2009 - Springer
Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential
equations and have been implemented in a number of commercial software packages. …
equations and have been implemented in a number of commercial software packages. …
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance
…, HM Jones, M Rowland, RD Jones… - Journal of …, 2011 - Wiley Online Library
The objective of this study was to evaluate the performance of various allometric and in vitro–in
vivo extrapolation (IVIVE) methodologies with and without plasma protein binding …
vivo extrapolation (IVIVE) methodologies with and without plasma protein binding …
Analysis of inactivation of SARS-CoV-2 by specimen transport media, nucleic acid extraction reagents, detergents, and fixatives
…, N Green, U Arnold, M Jones, MJ Hannah… - Journal of clinical …, 2020 - Am Soc Microbiol
The COVID-19 pandemic has necessitated a multifaceted rapid response by the scientific
community, bringing researchers, health officials, and industry together to address the ongoing …
community, bringing researchers, health officials, and industry together to address the ongoing …
Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations
HM Jones, JB Houston - Drug Metabolism and Disposition, 2004 - ASPET
The substrate depletion method is a popular approach used for the measurement of in vitro
intrinsic clearance (CL int ). However, the incubation conditions used in these studies can …
intrinsic clearance (CL int ). However, the incubation conditions used in these studies can …
Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling
Background: Food-induced changes in gastric emptying time, gastric pH and/or intestinal
fluid composition may have an impact on the pharmacokinetics of drugs. The aim of this work …
fluid composition may have an impact on the pharmacokinetics of drugs. The aim of this work …
PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution
R Do Jones, HM Jones, M Rowland, CR Gibson… - Journal of …, 2011 - Elsevier
The objective of this study was to evaluate the performance of various empirical, semimechanistic
and mechanistic methodologies with and without protein binding corrections for the …
and mechanistic methodologies with and without protein binding corrections for the …