… Jones 2010), the framing of ‘the war on terror’ (Coleman 2004; Dodds 2007; Hannah 2006)
and the justification and conduct of the interventions in Afghanistan and Iraq (Dalby 2009; …

Background The major aim of this study was to develop a strategy for predicting human
pharmacokinetics using physiologically based pharmacokinetic (PBPK) modelling. This was …

With efforts to reduce cytochrome P450-mediated clearance (CL) during the early stages of
drug discovery, transporter-mediated CL mechanisms are becoming more prevalent. …

The objective of this study is to assess the effectiveness of physiologically based
pharmacokinetic (PBPK) models for simulating human plasma concentration–time profiles for the …

Physiologically based pharmacokinetic (PBPK) models are composed of a series of differential
equations and have been implemented in a number of commercial software packages. …

The objective of this study was to evaluate the performance of various allometric and in vitro–in
vivo extrapolation (IVIVE) methodologies with and without plasma protein binding …

The COVID-19 pandemic has necessitated a multifaceted rapid response by the scientific
community, bringing researchers, health officials, and industry together to address the ongoing …

The substrate depletion method is a popular approach used for the measurement of in vitro
intrinsic clearance (CL int ). However, the incubation conditions used in these studies can …

Background: Food-induced changes in gastric emptying time, gastric pH and/or intestinal
fluid composition may have an impact on the pharmacokinetics of drugs. The aim of this work …

The objective of this study was to evaluate the performance of various empirical, semimechanistic
and mechanistic methodologies with and without protein binding corrections for the …