User profiles for Henrik Palmgren
Henrik PalmgrenIndustrial PhD student at AstraZeneca BioPharmaceuticals Verified email at astrazeneca.com Cited by 461 |
Transcriptional, functional, and mechanistic comparisons of stem cell–derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as …
CC Bell, VM Lauschke, SU Vorrink, H Palmgren… - Drug Metabolism and …, 2017 - ASPET
Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics
and toxicity are essential constituents of preclinical safety assessment pipelines for new …
and toxicity are essential constituents of preclinical safety assessment pipelines for new …
FOXK1 and FOXK2 regulate aerobic glycolysis
…, ME Lidell, J Naumann, S Haufs-Brusberg, H Palmgren… - Nature, 2019 - nature.com
Adaptation to the environment and extraction of energy are essential for survival. Some
species have found niches and specialized in using a particular source of energy, whereas …
species have found niches and specialized in using a particular source of energy, whereas …
[HTML][HTML] A CRISP (e) R view on kidney organoids allows generation of an induced pluripotent stem cell–derived kidney model for drug discovery
C Boreström, A Jonebring, J Guo, H Palmgren… - Kidney international, 2018 - Elsevier
Development of physiologically relevant cellular models with strong translatability to human
pathophysiology is critical for identification and validation of novel therapeutic targets. …
pathophysiology is critical for identification and validation of novel therapeutic targets. …
Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and …
…, KP Kanebratt, A Walentinsson, H Palmgren… - Biochemical …, 2018 - Elsevier
Primary human hepatocytes (PHH), HepaRG™, HepG2, and two sources of induced pluripotent
stem cell (iPSC) derived hepatocytes were characterized regarding gene expression …
stem cell (iPSC) derived hepatocytes were characterized regarding gene expression …
Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2
10.7554/eLife.40686.001 Dietary fatty acids are the main building blocks for cell membranes
in animals, and mechanisms must therefore exist that compensate for dietary variations. We …
in animals, and mechanisms must therefore exist that compensate for dietary variations. We …
[HTML][HTML] TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis
The fatty acid composition of phosphatidylethanolamine (PE) determines cellular metabolism,
oxidative stress, and inflammation. However, our understanding of how cells regulate PE …
oxidative stress, and inflammation. However, our understanding of how cells regulate PE …
Evolutionarily conserved long-chain Acyl-CoA synthetases regulate membrane composition and fluidity
The human AdipoR1 and AdipoR2 proteins, as well as their C. elegans homolog PAQR-2,
protect against cell membrane rigidification by exogenous saturated fatty acids by regulating …
protect against cell membrane rigidification by exogenous saturated fatty acids by regulating …
[HTML][HTML] Extensive transcription mis-regulation and membrane defects in AdipoR2-deficient cells challenged with saturated fatty acids
How cells maintain vital membrane lipid homeostasis while obtaining most of their constituent
fatty acids from a varied diet remains largely unknown. Here, we used transcriptomics, …
fatty acids from a varied diet remains largely unknown. Here, we used transcriptomics, …
[HTML][HTML] The transcription factor Foxp1 regulates aerobic glycolysis in adipocytes and myocytes
…, W Zhang, F Meng, S Subhash, H Palmgren… - Journal of Biological …, 2023 - ASBMB
In recent years, lactate has been recognized as an important circulating energy substrate
rather than only a dead-end metabolic waste product generated during glucose oxidation at …
rather than only a dead-end metabolic waste product generated during glucose oxidation at …
Elevated adipocyte membrane phospholipid saturation does not compromise insulin signaling
H Palmgren, K Petkevicius, S Bartesaghi… - Diabetes, 2023 - Am Diabetes Assoc
Increased saturated fatty acid (SFA) levels in membrane phospholipids have been implicated
in the development of metabolic disease. Here, we tested the hypothesis that increased …
in the development of metabolic disease. Here, we tested the hypothesis that increased …