Tumour necrosis factor α signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice
…, Y Oike, M Tomizawa, S Makino, T Ohkura, H Saito… - Gut, 2006 - gut.bmj.com
Background: While tumour necrosis factor α (TNF-α) appears to be associated with the
development of non-alcoholic steatohepatitis (NASH), its precise role in the pathogenesis of …
development of non-alcoholic steatohepatitis (NASH), its precise role in the pathogenesis of …
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular …
Y Saito, Y Kanai, T Nakagawa… - … journal of cancer, 2003 - Wiley Online Library
Alteration of DNA methylation is one of the most consistent epigenetic changes in human
cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic …
cancers. DNA methyltransferase (DNMT) 1 is a major enzyme involved in establishing genomic …
[HTML][HTML] Evidence-based clinical practice guidelines for liver cirrhosis 2015
H Fukui, H Saito, Y Ueno, H Uto, K Obara… - Journal of …, 2016 - Springer
The Japanese Society of Gastroenterology revised the evidence-based clinical practice
guidelines for liver cirrhosis in 2015. Eighty-three clinical questions were selected, and a …
guidelines for liver cirrhosis in 2015. Eighty-three clinical questions were selected, and a …
[PDF][PDF] Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice
…, K Shimamura, S Usui, H Ebinuma, H Saito… - …, 2014 - Wiley Online Library
Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the
underlying mechanisms of this association have not been clarified. We aimed to elucidate …
underlying mechanisms of this association have not been clarified. We aimed to elucidate …
Expression of mRNA for DNA methyltransferases and methyl-CpG–binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions …
Y Saito, Y Kanai, M Sakamoto, H Saito, H Ishii… - Hepatology, 2001 - Elsevier
To evaluate the significance of alterations in DNA methylation during human hepatocarcinogenesis,
we examined levels of mRNA for DNA methyltransferases and methyl-CpG-binding …
we examined levels of mRNA for DNA methyltransferases and methyl-CpG-binding …
A high-cholesterol diet exacerbates liver fibrosis in mice via accumulation of free cholesterol in hepatic stellate cells
…, R Irie, Y Okada, C Kurihara, H Ebinuma, H Saito… - Gastroenterology, 2012 - Elsevier
BACKGROUND & AIMS: Some studies have indicated that dietary cholesterol has a role in
the progression of liver fibrosis. We investigated the mechanisms by which dietary cholesterol …
the progression of liver fibrosis. We investigated the mechanisms by which dietary cholesterol …
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human …
Y Saito, Y Kanai, M Sakamoto, H Saito… - Proceedings of the …, 2002 - National Acad Sciences
DNA hypomethylation on pericentromeric satellite regions is an early and frequent event
associated with heterochromatin instability during human hepatocarcinogenesis. A DNA …
associated with heterochromatin instability during human hepatocarcinogenesis. A DNA …
Acoustic Radiation Force Impulse elastography for fibrosis evaluation in patients with chronic hepatitis C: an international multicenter study
…, C Fierbinteanu-Braticevici, A Petrisor, H Saito… - European journal of …, 2012 - Elsevier
AIM: The aim of this international multicenter study was to evaluate the reliability of Acoustic
Radiation Force Impulse (ARFI) elastography for predicting fibrosis severity, in patients with …
Radiation Force Impulse (ARFI) elastography for predicting fibrosis severity, in patients with …
Phase 2 study of stereotactic body radiotherapy and optional transarterial chemoembolization for solitary hepatocellular carcinoma not amenable to resection and …
…, K Matsunaga, H Ebinuma, K Imajo, Y Aoki, H Saito… - Cancer, 2016 - Wiley Online Library
BACKGROUND Curative treatment options for patients with early stage hepatocellular
carcinoma (HCC) include resection, liver transplantation, and percutaneous ablation therapy. …
carcinoma (HCC) include resection, liver transplantation, and percutaneous ablation therapy. …
Oxidative stress‐mediated apoptosis of hepatocytes exposed to acute ethanol intoxication
I Kurose, H Higuchi, S Miura, H Saito, N Watanabe… - …, 1997 - Wiley Online Library
The present study was designed to investigate whether acute ethanol intoxication increases
the production of active oxidants, and subsequently promotes apoptosis of hepatocytes. …
the production of active oxidants, and subsequently promotes apoptosis of hepatocytes. …