User profiles for Hiroaki Takayama

Hiroaki Takayama

Kanazawa University
Verified email at staff.kanazawa-u.ac.jp
Cited by 2054

[PDF][PDF] A liver-derived secretory protein, selenoprotein P, causes insulin resistance

H Misu, T Takamura, H Takayama, H Hayashi… - Cell metabolism, 2010 - cell.com
The liver may regulate glucose homeostasis by modulating the sensitivity/resistance of
peripheral tissues to insulin, by way of the production of secretory proteins, termed hepatokines. …

[HTML][HTML] Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria

…, N Matsuzawa-Nagata, H Takayama… - Journal of Biological …, 2009 - ASBMB
Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the
portal vein and may cause fatty liver disease and hepatic insulin resistance. However, …

[HTML][HTML] Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor …

…, S Nakane, T Kodaka, Y Suhara, H Takayama… - Journal of Biological …, 2000 - ASBMB
We examined the effect of 2-arachidonoylglycerol, an endogenous cannabinoid receptor
ligand, on the intracellular free Ca 2+ concentrations in HL-60 cells that express the …

[HTML][HTML] Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor: structure-activity relationship of 2-arachidonoylglycerol, ether-linked …

…, T Miyashita, S Kondo, Y Suhara, H Takayama… - Journal of Biological …, 1999 - ASBMB
An endogenous cannabimimetic molecule, 2-arachidonoylglycerol, induces a rapid,
transient increase in intracellular free Ca 2+ concentrations in NG108–15 cells through a …

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated …

H Misu, H Takayama, Y Saito, Y Mita, A Kikuchi… - Nature medicine, 2017 - nature.com
Exercise has numerous health-promoting effects in humans 1 ; however, individual
responsiveness to exercise with regard to endurance or metabolic health differs markedly 2 , 3 , 4 . …

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

F Lan, H Misu, K Chikamoto, H Takayama, A Kikuchi… - Diabetes, 2014 - Am Diabetes Assoc
Recent articles have reported an association between fatty liver disease and systemic insulin
resistance in humans, but the causal relationship remains unclear. The liver may contribute …

Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver

…, H Misu, T Ota, S Murata, H Hayashi, H Takayama… - Diabetes, 2013 - Am Diabetes Assoc
Chronic endoplasmic reticulum (ER) stress is a major contributor to obesity-induced insulin
resistance in the liver. However, the molecular link between obesity and ER stress remains to …

Efficient Synthesis of 2-Modified 1α,25-Dihydroxy-19-norvitamin D3 with Julia Olefination:  High Potency in Induction of Differentiation on HL-60 Cells

…, T Sugiura, K Waku, H Takayama… - The Journal of …, 2003 - ACS Publications
Six novel 2-substituted analogues of 1α,25-dihydroxy-19-norvitamin D 3 , 6a,b−8a,b, were
efficiently synthesized utilizing (−)-quinic acid as the A-ring precursor. The C2-modified A-…

Cytokine responses in the common carp, Cyprinus carpio L. treated with baker's yeast extract

G Biswas, H Korenaga, H Takayama, T Kono… - Aquaculture, 2012 - Elsevier
Cytokines are important regulators of the immune system and investigation of their functions
may prove useful for the development of vaccines and immunostimulants for aquaculture. …

Cytokine responses in the Japanese pufferfish (Takifugu rubripes) head kidney cells induced with heat-killed probiotics isolated from the Mongolian dairy products

…, H Korenaga, R Nagamine, H Takayama… - Fish & shellfish …, 2013 - Elsevier
Cytokine responses in the Japanese pufferfish (Takifugu rubripes) head kidney (HK) cells to
heat-killed lactic acid bacteria probiotics isolated from the Mongolian dairy products were …