User profiles for Hua Naranmandura

Hua naranmandura

Zhejiang University
Verified email at zju.edu.cn
Cited by 3133

[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds

…, QQ Wang, YH Jiang, C Wang, H Naranmandura - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have …

Trivalent arsenicals are bound to proteins during reductive methylation

H Naranmandura, N Suzuki… - Chemical research in …, 2006 - ACS Publications
Inorganic arsenic is converted to methylated metabolites, and most is excreted in urine as
dimethylarsinic acid in humans and animals. The present study was conducted to investigate …

Disruption of the arsenic (+ 3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention …

Z Drobna, H Naranmandura… - Chemical research in …, 2009 - ACS Publications
The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …

Comparative toxicity of arsenic metabolites in human bladder cancer EJ-1 cells

H Naranmandura, MW Carew, S Xu, J Lee… - Chemical research in …, 2011 - ACS Publications
The human bladder is one of the primary target organs for arsenic-induced carcinogenicity,
and arsenic metabolites in urine have been suspected to be directly involved in …

Arsenic metabolism and thioarsenicals

K Rehman, H Naranmandura - Metallomics, 2012 - academic.oup.com
Arsenic has received considerable attention in the world, since it can lead to a multitude of
toxic effects and has been recognized as a human carcinogen causing cancers. Here, we …

Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells

H Naranmandura, K Ibata… - Chemical research in …, 2007 - ACS Publications
… Anthony McKnight-Whitford, Baowei Chen, Hua Naranmandura, Chen Zhu and X. Chris Le
. New Method and Detection of High Concentrations of Monomethylarsonous Acid Detected …

Arsenic metabolism and thioarsenicals in hamsters and rats

H Naranmandura, N Suzuki, K Iwata… - Chemical Research …, 2007 - ACS Publications
The tissue distribution and chemical forms of arsenic were compared in two animal species
with different metabolic capacity and toxicity to arsenic. Hamsters and rats were given a …

Mitochondria Are the Main Target Organelle for Trivalent Monomethylarsonous Acid (MMAIII)-Induced Cytotoxicity

H Naranmandura, S Xu, T Sawata… - Chemical research in …, 2011 - ACS Publications
Excessive generation of reactive oxygen species (ROS) is considered to play an important
role in arsenic-induced carcinogenicity in the liver, lungs, and urinary bladder. However, little …

The effect of gene copy number and co-expression of chaperone on production of albumin fusion proteins in Pichia pastoris

Q Shen, M Wu, HB Wang, H Naranmandura… - Applied microbiology …, 2012 - Springer
Interleukin-1 receptor antagonist (IL1ra) is known to treat a number of diseases such as
rheumatoid arthritis and type 2 diabetes. However, the biological half-life of IL1ra is very short …

[HTML][HTML] Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function

…, Y Ogra, Z Gueroui, C Zhou, H Naranmandura… - Cancer Discovery, 2023 - AACR
Arsenic curative effects in APL rely on PML targeting. We report a PML B-box-2 structure that
drives trimer assembly, positioning a cysteine trio to form an arsenic-binding pocket, which …