User profiles for Hua Naranmandura
Hua naranmanduraZhejiang University Verified email at zju.edu.cn Cited by 3133 |
[HTML][HTML] Metabolism, toxicity and anticancer activities of arsenic compounds
…, QQ Wang, YH Jiang, C Wang, H Naranmandura - Oncotarget, 2017 - ncbi.nlm.nih.gov
A variety of studies indicated that inorganic arsenic and its methylated metabolites have
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have …
paradoxical effects, namely, carcinogenic and anticancer effects. Epidemiological studies have …
Trivalent arsenicals are bound to proteins during reductive methylation
H Naranmandura, N Suzuki… - Chemical research in …, 2006 - ACS Publications
Inorganic arsenic is converted to methylated metabolites, and most is excreted in urine as
dimethylarsinic acid in humans and animals. The present study was conducted to investigate …
dimethylarsinic acid in humans and animals. The present study was conducted to investigate …
Disruption of the arsenic (+ 3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention …
Z Drobna, H Naranmandura… - Chemical research in …, 2009 - ACS Publications
The arsenic (+3 oxidation state) methyltransferase (As3mt) gene encodes a 43 kDa protein
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …
that catalyzes methylation of inorganic arsenic. Altered expression of AS3MT in cultured …
Comparative toxicity of arsenic metabolites in human bladder cancer EJ-1 cells
H Naranmandura, MW Carew, S Xu, J Lee… - Chemical research in …, 2011 - ACS Publications
The human bladder is one of the primary target organs for arsenic-induced carcinogenicity,
and arsenic metabolites in urine have been suspected to be directly involved in …
and arsenic metabolites in urine have been suspected to be directly involved in …
Arsenic metabolism and thioarsenicals
K Rehman, H Naranmandura - Metallomics, 2012 - academic.oup.com
Arsenic has received considerable attention in the world, since it can lead to a multitude of
toxic effects and has been recognized as a human carcinogen causing cancers. Here, we …
toxic effects and has been recognized as a human carcinogen causing cancers. Here, we …
Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells
H Naranmandura, K Ibata… - Chemical research in …, 2007 - ACS Publications
… Anthony McKnight-Whitford, Baowei Chen, Hua Naranmandura, Chen Zhu and X. Chris Le
. New Method and Detection of High Concentrations of Monomethylarsonous Acid Detected …
. New Method and Detection of High Concentrations of Monomethylarsonous Acid Detected …
Arsenic metabolism and thioarsenicals in hamsters and rats
H Naranmandura, N Suzuki, K Iwata… - Chemical Research …, 2007 - ACS Publications
The tissue distribution and chemical forms of arsenic were compared in two animal species
with different metabolic capacity and toxicity to arsenic. Hamsters and rats were given a …
with different metabolic capacity and toxicity to arsenic. Hamsters and rats were given a …
Mitochondria Are the Main Target Organelle for Trivalent Monomethylarsonous Acid (MMAIII)-Induced Cytotoxicity
H Naranmandura, S Xu, T Sawata… - Chemical research in …, 2011 - ACS Publications
Excessive generation of reactive oxygen species (ROS) is considered to play an important
role in arsenic-induced carcinogenicity in the liver, lungs, and urinary bladder. However, little …
role in arsenic-induced carcinogenicity in the liver, lungs, and urinary bladder. However, little …
The effect of gene copy number and co-expression of chaperone on production of albumin fusion proteins in Pichia pastoris
Q Shen, M Wu, HB Wang, H Naranmandura… - Applied microbiology …, 2012 - Springer
Interleukin-1 receptor antagonist (IL1ra) is known to treat a number of diseases such as
rheumatoid arthritis and type 2 diabetes. However, the biological half-life of IL1ra is very short …
rheumatoid arthritis and type 2 diabetes. However, the biological half-life of IL1ra is very short …
[HTML][HTML] Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function
…, Y Ogra, Z Gueroui, C Zhou, H Naranmandura… - Cancer Discovery, 2023 - AACR
Arsenic curative effects in APL rely on PML targeting. We report a PML B-box-2 structure that
drives trimer assembly, positioning a cysteine trio to form an arsenic-binding pocket, which …
drives trimer assembly, positioning a cysteine trio to form an arsenic-binding pocket, which …