User profiles for Hyunyoung Jeong
Hyunyoung JeongPurdue University Verified email at purdue.edu Cited by 3228 |
Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes
H Jeong - Expert opinion on drug metabolism & toxicology, 2010 - Taylor & Francis
Importance of the field: Medication use during pregnancy is prevalent, but pharmacokinetic
information of most drugs used during pregnancy is lacking in spite of known effects of …
information of most drugs used during pregnancy is lacking in spite of known effects of …
Interindividual variability in cytochrome P450–mediated drug metabolism
The cytochrome P450 (P450) enzymes are the predominant enzyme system involved in human
drug metabolism. Alterations in the expression and/or activity of these enzymes result in …
drug metabolism. Alterations in the expression and/or activity of these enzymes result in …
Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone
Results from clinical studies suggest that pregnancy alters hepatic drug metabolism in a
cytochrome P450 (P450) isoform-specific manner, and rising concentrations of female …
cytochrome P450 (P450) isoform-specific manner, and rising concentrations of female …
Up-regulation of UDP-glucuronosyltransferase (UGT) 1A4 by 17β-estradiol: a potential mechanism of increased lamotrigine elimination in pregnancy
H Chen, K Yang, S Choi, JH Fischer, H Jeong - Drug Metabolism and …, 2009 - ASPET
Oral clearance of lamotrigine, an antiepileptic drug commonly used in pregnant women, is
increased in pregnancy by unknown mechanisms. In this study, we show that 17β-estradiol (E …
increased in pregnancy by unknown mechanisms. In this study, we show that 17β-estradiol (E …
[HTML][HTML] Ten years' experience with the CYP2D6 activity score: a perspective on future investigations to improve clinical predictions for precision therapeutics
The seminal paper on the CYP2D6 Activity Score (AS) was first published ten years ago and,
since its introduction in 2008, it has been widely accepted in the field of pharmacogenetics. …
since its introduction in 2008, it has been widely accepted in the field of pharmacogenetics. …
Therapeutic monitoring of mycophenolate mofetil
H Jeong, B Kaplan - Clinical Journal of the American Society of …, 2007 - journals.lww.com
Mycophenolate mofetil (MMF) has become the single most used immunosuppressant in
solid-organ transplantation. Despite a well-documented relationship and efficacy (in terms of …
solid-organ transplantation. Despite a well-documented relationship and efficacy (in terms of …
Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination
H Jeong, S Choi, JW Song, H Chen, JH Fischer - Xenobiotica, 2008 - Taylor & Francis
The authors recently reported the increased oral clearance of labetalol in pregnant women.
To elucidate the mechanism of the elevated oral clearance, it was hypothesized that female …
To elucidate the mechanism of the elevated oral clearance, it was hypothesized that female …
Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites
Tacrolimus exhibits low and variable drug exposure after oral dosing, but the contributing
factors remain unclear. Based on our recent report showing a positive correlation between …
factors remain unclear. Based on our recent report showing a positive correlation between …
[HTML][HTML] Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine …
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative
breast cancer promote cancer progression through autocrine serotonin signaling | Molecular …
breast cancer promote cancer progression through autocrine serotonin signaling | Molecular …
[HTML][HTML] The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus
In Staphylococcus aureus, an important Gram-positive human pathogen, the SaeRS two-component
system is essential for the virulence and a good target for the development of anti-…
system is essential for the virulence and a good target for the development of anti-…