Detailed cytochrome P450 (P450) inhibition profiles are now required for the registration of
novel molecular entities. This method uses combined substrates (phenacetin, diclofenac, S-…

The glucuronidation of (1S,2R,3R,5R)-3-(hydroxymethyl)-5-[7-{[(1R,2S)-2-phenylcyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]cyclopentane-1,2-diol
(…

The thermospray liquid chromatography/mass spectrometry (LC/MS) interface has had a
major impact on the direct analysis of the metabolic fate of xenobiotics in complex biological …

The structural identification of drug metabolites has been carried out using thermospray
liquid chromatography/mass spectrometry (LC/MS). It has allowed the direct analysis of …

Non‐volatile nitrosamines exemplified by nitroso amino acids, ‐dipeptides, ‐oxazolidines
and ‐thiazolidines have been analysed by moving belt liquid chromatography/mass …

This paper describes the development and application of a combined thermospray liquid
chromatographic/mass spectrometric and liquid chromatographic/tandem mass spectrometric …

During analytical method development for metabolite detection, where isobaric components
(ie, similar nominal or exact m/z) can often coelute, ion suppression is a critical but often …

Abbreviations: HPLC, high-performance liquid chromatography; MS, mass spectrometry;
NMR, nuclear magnetic resonance; ROESY, rotating-frame Overhauser effect spectroscopy; …

Three river conceptual models make differing predictions about the major source of primary
production in lowland rivers, acknowledging the importance of primary productivity in the …

… This research might well suggest that social and cultural attempts to increase optimism
through cognitive behavioral therapy and similar techniques (Beattie 2011a) could be disastrous …