Radiotherapy is a major part in the treatment of most common cancers, but many patients
experience local recurrence with metastatic disease. In evaluating response biomarkers, we …

There is increasing evidence that hypoxia-regulated gene expression influences tumor
aggressiveness, contributing to the poorer outcome of patients with hypoxic tumors. The role of …

Background: Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand
breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy and …

Solid tumors with disorganized, insufficient blood supply contain hypoxic cells that are resistant
to radiotherapy and chemotherapy. Drug resistance, an obstacle to curative treatment of …

Solid tumors with areas of low oxygen tension (hypoxia) have a poor prognosis, as celts in
this environment often survive radiation and chemotherapy. In this report we describe how …

The presence of hypoxia in tumours results in the overexpression of certain genes, which
are controlled via the transcription factor HIF‐1. Hypoxic cells are known to be radioresistant …

In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy
as part of their treatment, which is one of the most cost-effective cancer treatments. …

Background The gastrointestinal tract microbiota (GTM) of mammals is a complex microbial
consortium, the composition and activities of which influences mucosal development, …

Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more
malignant phenotype. The expression of interleukin-8 (IL-8) plays an important role in the …

In recent years the idea of using gene therapy as a modality in the treatment of diseases other
than genetically inherited, monogenic disorders has taken root. This is particularly obvious …