Study on the interaction of catechins with human serum albumin using spectroscopic and electrophoretic techniques

L Trnková, I Boušová, V Staňková, J Dršata - Journal of Molecular Structure, 2011 - Elsevier
The interaction between eight naturally occurring flavanols (catechin, epicatechin,
gallocatechin, epigallocatechin, catechin gallate, epicatechin gallate, gallocatechin gallate, and …

Possibilities to increase the effectiveness of doxorubicin in cancer cells killing

V Hanušová, I Boušová, L Skálová - Drug metabolism reviews, 2011 - Taylor & Francis
Anthracycline antibiotic doxorubicin (DOX) belongs among the most important antineoplastics
used in cancer therapy. Unfortunately, its cytostatic effect in therapeutic doses is frequently …

Hepatotoxicity of monoterpenes and sesquiterpenes

T Zárybnický, I Boušová, M Ambrož, L Skálová - Archives of Toxicology, 2018 - Springer
Public interest in natural therapies has increased significantly over past decades. Herbs and
herbal products are extensively consumed worldwide and they are generally considered as …

[HTML][HTML] The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells

M Ambrož, I Boušová, A Skarka, V Hanušová… - Molecules, 2015 - mdpi.com
The sesquiterpenes β-caryophyllene, β-caryophyllene oxide (CAO), α-humulene (HUM),
trans-nerolidol (NER), and valencene (VAL) are substantial components of the essential oil …

Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences

I Boušová, L Skálová - Drug metabolism reviews, 2012 - Taylor & Francis
Many studies reviewed herein demonstrated the potency of some flavonoids to modulate
the activity and/or expression of glutathione S-transferases (GSTs). Because GSTs play a …

The role of UDP-glycosyltransferases in xenobioticresistance

…, P Matoušková, R Podlipná, I Boušová… - Drug Metabolism …, 2022 - Taylor & Francis
Uridine diphosphate sugar-utilizing glycosyltransferases (UGTs) are an enzyme superfamily
that catalyzes glycosyl residues transfer from activated nucleotide sugars to acceptor …

[HTML][HTML] Antiproliferative effects of hop-derived prenylflavonoids and their influence on the efficacy of oxaliplatine, 5-fluorouracil and irinotecan in human colorectalC …

…, K Lněničková, P Matoušková, L Skálová, I Boušová - Nutrients, 2019 - mdpi.com
Beer, the most popular beverage containing hops, is also frequently consumed by cancer
patients. Moreover, non-alcoholic beer, owing to its nutritional value and high content of …

[HTML][HTML] Age-related changes in hepatic activity and expression of detoxification enzymes in male rats

…, H Bártíková, J Hlaváčová, I Boušová - BioMed research …, 2013 - hindawi.com
Process of aging is accompanied by changes in the biotransformation of xenobiotics and
impairment of normal cellular functions by free radicals. Therefore, this study was designed to …

[HTML][HTML] Reference genes for real-time PCR quantification of messenger RNAs and microRNAs in mouse model of obesity

P Matoušková, H Bártíková, I Boušová, V Hanušová… - PloS one, 2014 - journals.plos.org
Obesity and metabolic syndrome is increasing health problem worldwide. Among other
ways, nutritional intervention using phytochemicals is important method for treatment and …

[HTML][HTML] Inter-individual variability in acute toxicity of R-pulegone and R-menthofuran in human liver slices and their influence on miRNA expression changes in …

…, B Lancošová, Z Šubrt, L Skálová, I Boušová - International Journal of …, 2018 - mdpi.com
Monoterpenes R-pulegone (PUL) and R-menthofuran (MF), abundant in the Lamiaceae
family, are frequently used in herb and food products. Although their hepatotoxicity was shown …