[HTML][HTML] Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine

T Ishizuka, I Fujimori, M Kato, C Noji-Sakikawa… - Journal of biological …, 2010 - ASBMB
Olmesartan medoxomil (OM) is a prodrug type angiotensin II type 1 receptor antagonist
widely prescribed as an antihypertensive agent. Herein, we describe the identification and …

Real-time monitoring of metabolic reactions by microdialysis in combination with tandem mass spectrometry: hydrolysis of CS-866 in vitro in human and rat plasma …

N Kobayashi, I Fujimori, M Watanabe, T Ikeda - Analytical biochemistry, 2000 - Elsevier
Microdialysis combined with tandem mass spectrometry was used to monitor the rapid
hydrolysis of CS-866, a new prodrug-type angiotensin II receptor antagonist, in vitro in rat and …

Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma …

T Ishizuka, I Fujimori, A Nishida, H Sakurai… - Drug Metabolism and …, 2012 - ASPET
Olmesartan medoxomil (OM) is a prodrug-type angiotensin II type 1 receptor antagonist.
The OM-hydrolyzing enzyme responsible for prodrug bioactivation was purified from human …

Pharmacological and pharmacokinetic study of olmesartan medoxomil in animal diabetic retinopathy models

…, N Arakawa, Y Shimizu, Y Yoshigae, I Fujimori… - European journal of …, 2005 - Elsevier
A close relationship between the renin–angiotensin system and the pathophysiology of diabetic
retinopathy has been suggested, several angiotensin II type 1 receptor (angiotensin AT1 …

Power-counting and renormalizability in Lifshitz scalar theory

T Fujimori, T Inami, K Izumi, T Kitamura - Physical Review D, 2015 - APS
We study the renormalizability in theories of a self-interacting Lifshitz scalar field. We show
that although the statement of power-counting is true at one-loop order, in generic cases …

Tree-level unitarity and renormalizability in Lifshitz scalar theory

T Fujimori, T Inami, K Izumi… - Progress of Theoretical …, 2016 - academic.oup.com
We study unitarity and renormalizability in the Lifshitz scalar field theory, which is characterized
by an anisotropic scaling between the space and time directions. Without the Lorentz …

Increased nuclear localization of transcription factor Y-box binding protein 1 accompanied by up-regulation of P-glycoprotein in breast cancer pretreated with …

…, K Shingu, S Tsuchiya, K Kohno, M Fujimori - Clinical cancer …, 2005 - AACR
Purpose: The Y-box binding protein 1 (YB-1) regulates expression of P-glycoprotein encoded
by the MDR1 gene. There have been no previous studies regarding the involvement of YB-…

Small bowel obstruction caused by the ingestion of a wooden toothpick: the CT findings and a literature review

J Izumi, K Satoh, W Iwasaki, T Miura, S Fujimori - Internal Medicine, 2017 - jstage.jst.go.jp
We present a case in which the accidental ingestion of a toothpick caused duodenal perforation
and small intestinal obstruction. A 58-year-old man visited our emergency room with …

[HTML][HTML] Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

T Akiyama, N Suzuki, M Ishikawa, K Fujimori, T Sone… - …, 2019 - thelancet.com
Background The characteristic structure of motor neurons (MNs), particularly of the long
axons, becomes damaged in the early stages of amyotrophic lateral sclerosis (ALS). However, …

A Wearable Healthcare System With a 13.7 A Noise Tolerant ECG Processor

…, K Marumoto, T Fuchikami, Y Fujimori… - … Circuits and Systems, 2014 - ieeexplore.ieee.org
To prevent lifestyle diseases, wearable bio-signal monitoring systems for daily life monitoring
have attracted attention. Wearable systems have strict size and weight constraints, which …