The development of chiral small organic molecules that serve as Lewis base catalysts
promoting highly stereoselective transformations has been the subject of intense research over …

This review first outlines general considerations on phosphinic acids and derivatives as
bioisosteric groups. The next sections present key aspects of phosphinic acid-based molecules …

This paper reports the design and the synthesis of a new family of compounds, the phostines,
belonging to the [1,2]oxaphosphinane family. Twenty-six compounds have been screened …

Although there is a significant effort in the design of a selective CDK9/CycT1 inhibitor, no
compound has been proven to be a specific inhibitor of this kinase so far. The aim of this …

The sigma-1 (σ 1 ) receptor is an endoplasmic reticulum (ER) chaperone protein, enriched in
mitochondria-associated membranes. Its activation triggers physiological responses to ER …

α-Aminophosphonates are an important class of biologically active compounds, attracting
considerable attention in medicinal chemistry, by inhibiting enzymes involved in amino acid …

New phosphorus heterocycles were synthesized using RCM reaction. They were prepared
from unsymmetrical or polyfunctional insaturated precursor in 50 to 87% yields solving the …

We report herein an efficient synthesis of diversely polysubstituted imidazo[1,2-a]pyridines,
a family of aza-heterocycles endowed with numerous biological properties, through a …

A highly convergent synthesis of bis(triazolylphosphane oxides) was developed by a
tandem copper-mediated Huisgen reaction–oxidative coupling. The phosphane oxides were …

This paper reports the design and synthesis of C-glycoside mimetics (d-glycero-d-talo- and d-glycero-d-galactopyranose
analogues), a subset of the recently published phostines, …