The epigenome is defined by DNA methylation patterns and the associated post-translational
modifications of histones. This histone code determines the expression status of individual …

The two domains in clinical pharmacology dealing with optimizing dosing recommendations
are pharmacokinetics and pharmacodynamics. However, the usefulness of these …

Angiogenesis is crucial for development and metastasis of tumors, and vascular endothelial
growth factor (VEGF) is a key mediator of this process. The importance of VEGF in …

… Acharya a b , Jürgen Venitz b , William D. Figg a , Alex Sparreboom a …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Sorafenib is a multikinase inhibitor
with activity against B‐raf, C‐raf, VEGFR2, PDGFRβ and FGFR1. • Sorafenib is clinically …

Purpose: To determine the maximum-tolerated dose (MTD) and toxicity profile of the novel
anticancer agent, 2-methoxyestradiol (2ME2) administered orally, in patients with solid tumors…

Purpose: To determine if sorafenib is associated with a 4-month probability of progression-free
survival, which is consistent with 50%, as determined by clinical, radiographic, and …

WHAT IS ALRADY KNOWN ABOUT THIS SUBJECT • Warfarin anticoagulation therapy is
commonly administered to patients with pulmonary arterial hypertension (PAH) to reduce the …

Aerosolized propylene glycol (PG) was generated as log-normally distributed particulate
clouds in different concentrations using a novel capillary aerosol generator (CAG) and …

Background Hypertension (HT) and hand-foot skin reactions (HFSR) may be related to the
activity of bevacizumab and sorafenib. We hypothesized that these toxicities would …