User profiles for J. H. Lin

JinHan Lin

National Dong Hwa University
Verified email at gms.ndhu.edu.tw
Cited by 1907

Bisphosphonates: a review of their pharmacokinetic properties

JH Lin - Bone, 1996 - Elsevier
Bisphosphonates are a unique class of drugs. As a family, they are characterized
pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are …

Role of P-glycoprotein in pharmacokinetics: clinical implications

JH Lin, M Yamazaki - Clinical pharmacokinetics, 2003 - Springer
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions
as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and in vivo …

Inhibition and induction of cytochrome P450 and the clinical implications

JH Lin, AYH Lu - Clinical pharmacokinetics, 1998 - Springer
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role
in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic broad …

IRE1 signaling affects cell fate during the unfolded protein response

JH Lin, H Li, D Yasumura, HR Cohen, C Zhang… - science, 2007 - science.org
Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed
the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) …

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

J Hollien, JH Lin, H Li, N Stevens, P Walter… - Journal of Cell …, 2009 - rupress.org
Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring
enzyme 1), a transmembrane protein activated by protein misfolding in the ER. …

[HTML][HTML] TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

…, C Tsatsanis, D Kontoyiannis, K Stamatakis, JH Lin… - Cell, 2000 - cell.com
Tpl 2 knockout mice produce low levels of TNF-α when exposed to lipopolysaccharide (LPS)
and they are resistant to LPS/D-Galactosamine-induced pathology. LPS stimulation of …

Role of pharmacokinetics and metabolism in drug discovery and development

JH Lin, AYH Lu - Pharmacological reviews, 1997 - ASPET
Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …

Structure and properties of cast binary Ti–Mo alloys

WF Ho, CP Ju, JHC Lin - Biomaterials, 1999 - Elsevier
Structure and properties of a series of binary Ti–Mo alloys with molybdenum contents
ranging from 6 to 20 wt% have been investigated. Experimental results indicated that crystal …

Endoplasmic reticulum stress in disease pathogenesis

JH Lin, P Walter, TSB Yen - Annu. Rev. Pathol. Mech. Dis., 2008 - annualreviews.org
The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and
secretory proteins, which, collectively, represent a large fraction of the total protein output of a …

One‐dimensional metal‐oxide nanostructures: recent developments in synthesis, characterization, and applications

RS Devan, RA Patil, JH Lin… - Advanced Functional …, 2012 - Wiley Online Library
1D metal‐oxide nanostructures have attracted much attention because metal oxides are the
most fascinating functional materials. The 1D morphologies can easily enhance the unique …