User profiles for J. H. Lin
JinHan LinNational Dong Hwa University Verified email at gms.ndhu.edu.tw Cited by 1910 |
Bisphosphonates: a review of their pharmacokinetic properties
JH Lin - Bone, 1996 - Elsevier
Bisphosphonates are a unique class of drugs. As a family, they are characterized
pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are …
pharmacologically by their ability to inhibit bone resorption, whereas, pharmacokinetically, they are …
Role of P-glycoprotein in pharmacokinetics: clinical implications
JH Lin, M Yamazaki - Clinical pharmacokinetics, 2003 - Springer
P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions
as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and in vivo …
as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and in vivo …
Inhibition and induction of cytochrome P450 and the clinical implications
JH Lin, AYH Lu - Clinical pharmacokinetics, 1998 - Springer
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important role
in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic broad …
in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic broad …
IRE1 signaling affects cell fate during the unfolded protein response
JH Lin, H Li, D Yasumura, HR Cohen, C Zhang… - science, 2007 - science.org
Endoplasmic reticulum (ER) stress activates a set of signaling pathways, collectively termed
the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) …
the unfolded protein response (UPR). The three UPR branches (IRE1, PERK, and ATF6) …
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring
enzyme 1), a transmembrane protein activated by protein misfolding in the ER. …
enzyme 1), a transmembrane protein activated by protein misfolding in the ER. …
[HTML][HTML] TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
Tpl 2 knockout mice produce low levels of TNF-α when exposed to lipopolysaccharide (LPS)
and they are resistant to LPS/D-Galactosamine-induced pathology. LPS stimulation of …
and they are resistant to LPS/D-Galactosamine-induced pathology. LPS stimulation of …
Role of pharmacokinetics and metabolism in drug discovery and development
JH Lin, AYH Lu - Pharmacological reviews, 1997 - ASPET
Drug research encompasses several diverse disciplines united by a common goal, namely
the development of novel therapeutic agents. The search for new drugs can be divided …
the development of novel therapeutic agents. The search for new drugs can be divided …
Structure and properties of cast binary Ti–Mo alloys
WF Ho, CP Ju, JHC Lin - Biomaterials, 1999 - Elsevier
Structure and properties of a series of binary Ti–Mo alloys with molybdenum contents
ranging from 6 to 20 wt% have been investigated. Experimental results indicated that crystal …
ranging from 6 to 20 wt% have been investigated. Experimental results indicated that crystal …
Endoplasmic reticulum stress in disease pathogenesis
JH Lin, P Walter, TSB Yen - Annu. Rev. Pathol. Mech. Dis., 2008 - annualreviews.org
The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and
secretory proteins, which, collectively, represent a large fraction of the total protein output of a …
secretory proteins, which, collectively, represent a large fraction of the total protein output of a …
One‐dimensional metal‐oxide nanostructures: recent developments in synthesis, characterization, and applications
1D metal‐oxide nanostructures have attracted much attention because metal oxides are the
most fascinating functional materials. The 1D morphologies can easily enhance the unique …
most fascinating functional materials. The 1D morphologies can easily enhance the unique …