Oxygen-sensitive and-insensitive nitroreduction by Escherichia coli and rat hepatic microsomes.

…, RP Mason, J Hovsepian, JL Holtzman - Journal of Biological …, 1979 - ASBMB
Nitrofurazone is shown to undergo an initial 1-electron (oxygen-sensitive) or 2- or more electron
(oxygen-insensitive) reduction by partially purified nitroreductases from Escherichia coli. …

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

RP Mason, JL Holtzman - Biochemical and biophysical research …, 1975 - Elsevier
Many nitroreductases are strongly inhibited by oxygen. The first intermediate of nitroreductase
activity, the nitroaromatic anion free radical, cannot be detected in aerobic microsomal …

Potentiation of acetaminophen hepatotoxicity by alcohol

CJ McClain, JP Kromhout, FJ Peterson, JL Holtzman - Jama, 1980 - jamanetwork.com
Severe liver failure developed in three chronic alcoholics after they ingested acetaminophen
for therapeutic reasons. The clinical course was characterized by SGOT levels of 5,000 to …

Mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates

RP Mason, JL Holtzman - Biochemistry, 1975 - ACS Publications
Ronald Paul Mason* and Jordan L. Holtzman abstract: Electron spin resonance spectra are
observed during the enzymatic reduction of many nitrophenyl deriva-tives by rat hepatic …

The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of …

…, LM Dunning, JL Holtzman - The Journals of …, 2006 - academic.oup.com
The endoplasmic reticulum (ER) chaperones are highly conserved proteins that catalyze the
posttranslational processing of all secretory and membrane proteins. Our studies suggest …

[HTML][HTML] Low serum glutathione peroxidase activity is associated with increased cardiovascular mortality in individuals with low HDLc's

…, RV Luepker, DR Jacobs Jr, JL Holtzman - PloS one, 2012 - journals.plos.org
Background Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione
peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity …

In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind β-amyloid

…, AT Davis, WG Wood, RA Kratzke, JL Holtzman - Biochemical and …, 2005 - Elsevier
The β-amyloids (abetas) are the major components of the plaque observed in the brains of
patients with Alzheimer’s disease. The conundrum is that although they are produced in …

Physiologic concentrations of homocysteine inhibit the human plasma GSH peroxidase that reduces organic hydroperoxides

N Chen, Y Liu, CD Greiner, JL Holtzman - Journal of laboratory and clinical …, 2000 - Elsevier
The plasma reduced glutathione (GSH) selenoperoxidase is a highly conserved enzyme.
Furthermore, a small clinical study reported that patients with severe atherosclerosis had low …

The pharmacokinetics of daunomycin in man

…, NR Bachur, JL Holtzman - Clinical Pharmacology & …, 1971 - Wiley Online Library
Through the use of fluorescence assay methods, the plasma levels, urinary excretion, and
tissue levels of daunomycin and its fluorescent metabolites were determined in patients …

Drug metabolism by rat and human hepatic microsomes in response to interaction with H2-receptor antagonists

RG Knodell, JL Holtzman, DL Crankshaw, NM Steele… - Gastroenterology, 1982 - Elsevier
Cimetidine has been reported to decrease plasma clearance of drugs in humans and
animals. This reduction in hepatic drug metabolism could be due to cimetidine's intrinsic H 2 -…