Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

HML Davies, JR Manning - Nature, 2008 - nature.com
Novel reactions that can selectively functionalize carbon–hydrogen bonds are of intense
interest to the chemical community because they offer new strategic approaches for synthesis. …

Respiratory syncytial viral infection in infants with congenital heart disease

…, C Alexson, PJ Harris, JA Manning - … England Journal of …, 1982 - Mass Medical Soc
Occasional reports have suggested that infants with congenital heart disease may have an
increased risk of severe illness from respiratory syncytial virus (RSV) infection. We …

One-pot synthesis of highly functionalized pyridines via a rhodium carbenoid induced ring expansion of isoxazoles

JR Manning, HML Davies - Journal of the American Chemical …, 2008 - ACS Publications
A concise one-pot synthesis of highly functionalized pyridines has been developed. The first
step in the reaction sequence is the formal insertion of rhodium vinylcarbenoids across the N…

Metabolism and disposition of dasatinib after oral administration to humans

LJ Christopher, D Cui, C Wu, R Luo, JA Manning… - Drug metabolism and …, 2008 - ASPET
SPRYCEL (dasatinib, BMS-354825; Bristol-Myers Squibb, Princeton, NJ), a multiple kinase
inhibitor, is currently approved to treat chronic myelogenous leukemia and Philadelphia …

Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity

S Sugio, GA Petsko, JM Manning, K Soda, D Ringe - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received May 18, 1995® abstract: The three-dimensional structure of D-amino
acid aminotransferase (d-AAT) in the pyridoxamine phosphate form has …

Dynamic pressure loads associated with twin supersonic plume resonance

JM Seiner, JC Manning, MK Ponton - AIAA Journal, 1988 - arc.aiaa.org
D= jet exit diameter Dj= fully expanded jet plume diameter, Eq.(4) fs= plume resonance
frequency L= average plume shock cell spacing, Eq.(5) Mc= convection Mach number large …

Potassium Cyanate as an Inhibitor of the Sickling of Erythrocytes In Vitro

A Cerami, JM Manning - Proceedings of the National …, 1971 - National Acad Sciences
The recent use of urea as a treatment for the crisis phase of sickle-cell anemia has prompted
us to investigate the possibility that cyanate, which is in equilibrium with urea in solution, …

Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase

JM Manning, S Moore, WB Rowe, A Meister - Biochemistry, 1969 - ACS Publications
… this question, L-methionine sulfoximine phosphate (obtained from enzyme inhibited by
incubation with L-methionine SR-sulfoximine, ATP, andMg2+) was converted into the - -L-leucyl …

[HTML][HTML] Direct interaction between the Gulf Stream and the shelfbreak south of New England

…, RE Todd, AJ Plueddemann, M Andres, JP Manning - Scientific reports, 2012 - nature.com
Sea surface temperature imagery, satellite altimetry and a surface drifter track reveal an unusual
tilt in the Gulf Stream path that brought the Gulf Stream to 39.9N near the Middle Atlantic …

Initial observations of the 2005 Alexandrium fundyense bloom in southern New England: General patterns and mechanisms

…, MJ Mickelson, KE Keay, PS Libby, JP Manning… - Deep Sea Research …, 2005 - Elsevier
From May to July, 2005, an extensive bloom of Alexandrium fundyense occurred along the
coast of southern New England. The outbreak eventually closed shellfish beds from central …