The metabolism and disposition of [ 14 C]apixaban, a potent, reversible, and direct inhibitor
of coagulation factor Xa, were investigated in mice, rats, rabbits, dogs, and humans after a …

INTRODUCTION: The properties and potential liabilities of drug candidate are investigated
in detailed ADME assays and in toxicity studies, where findings are placed in context of …

This study was carried out to determine the metabolic pathways of buspirone and cytochrome
P450 (P450) isoform(s) responsible for buspirone metabolism in human liver microsomes (…

TopCount, a microplate scintillation counter (MSC), has been recently employed as an off-line
liquid radiochromatographic detector for radioactive metabolite profile analysis. The …

MaxiPost [(3S)-(+)-(5-chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one);
BMS-204352] is an investigational maxi-K channel opener to treat ischemic …

Background and purpose To gauge the potential effect of mode of content delivery on overall
student success in a pharmaceutical sciences course in a doctor of pharmacy program. …

(3S)-(+)-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)-2H-indole-2-one)
(MaxiPost, BMS-204352) is a potent and specific opener for maxi-K channels and has …

Ifetroban is a potent and selective thromboxane receptor antagonist. This study was conducted
to characterize the pharmacokinetics, absolute bioavailability, and disposition of ifetroban …

Muraglitazar (Pargluva), a dual α/γ peroxisome proliferator-activated receptor (PPAR)
activator, has both glucose- and lipid-lowering effects in animal models and in patients with …

This study describes the pharmacokinetic parameters of gemopatrilat, a potent vasopeptidase
inhibitor, in humans and the comparative biotransformation of the compound in rats, dogs, …