Ethacrynic acid, a potent inhibitor of glutathione S-transferases (GST), has been shown to
enhance the cytotoxicity of chlorambucil in drug resistant cell lines, but a definite mechanism …

In the present study it has been shown that ethacrynic acid can inhibit glutathione S-transferase
(GST) of the pi-class irreversibly. [ 14 C]Ethacrynic acid, 0.8 nmol/nmol human P1-1 and …

In this study a polymorphism in the conjugating activity of human erythrocyte cytosol towards
the dihaloethane, ethylene dibromide (EDB; 1,2-dibromoethane) was found. Two out of 12 …

The active site of glutathione S‐transferase isoenzyme 4–4, purified from rat liver, was studied
by chemical modification. Tetrachloro‐1,4‐benzoquinone, a compound previously shown …

Quantitative structure−activity relationships (QSAR's) are described for the rate of conjugation
of a series of fluoronitrobenzenes with cytosolic as well as with two major alpha and mu …

Several cationic amphiphilic compounds are known to induce phospholipidosis, a condition
primarily characterized by excessive accumulation of phospholipids in different cell types, …

The reversible and irreversible inhibition of human glutathione S-transferases (GST) by
dopamine, α-methyldopa and their 5-S-glutathionyl conjugates (termed 5-GSDA and 5-…

The glutathione S-transferase (GST) activity towards 1-chloro-2,4-dinitrobenzene in intact
human IGR-39 melanoma cells was determined by the quantification by HPLC-analysis of the …

In the present study the irreversible inhibition of human glutathione S-transferase P1-1 (GSTP1-1)
by α, β-unsaturated aldehydes and ketones was studied. When GSTP1-1 was …

The quinones tetrachloro-1,4-benzoquinone (1,4-TCBQ) and its glutathione conjugate (GS-1,4-TCBQ)
are potent irreversible inhibitors of most human glutathione S-transferase (GST) …