Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
JS Gujral, TR Knight, A Farhood, ML Bajt… - Toxicological …, 2002 - academic.oup.com
Acetaminophen (AAP) overdose can cause severe liver injury and liver failure in experimental
animals and humans. Recently, several authors proposed that apoptosis might be a major …
animals and humans. Recently, several authors proposed that apoptosis might be a major …
Mechanism of cell death during warm hepatic ischemia–reperfusion in rats: apoptosis or necrosis?
JS Gujral, TJ Bucci, A Farhood, H Jaeschke - Hepatology, 2001 - journals.lww.com
Reperfusion injury can cause liver dysfunction after cold storage and warm ischemia.
Recently it has been suggested that more than 50% of hepatocytes and sinusoidal endothelial …
Recently it has been suggested that more than 50% of hepatocytes and sinusoidal endothelial …
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice
JS Gujral, A Farhood, ML Bajt, H Jaeschke - Hepatology, 2003 - Elsevier
Obstruction of the common bile duct in a variety of clinical settings leads to cholestatic liver
injury. An important aspect of this injury is hepatic inflammation, with neutrophils as the …
injury. An important aspect of this injury is hepatic inflammation, with neutrophils as the …
Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice
JS Gujral, J Liu, A Farhood… - American Journal of …, 2004 - journals.physiology.org
Cholestasis-induced liver injury during bile duct obstruction causes an acute inflammatory
response. To further characterize the mechanisms underlying the neutrophil-induced cell …
response. To further characterize the mechanisms underlying the neutrophil-induced cell …
Apoptosis and necrosis in liver disease
H Jaeschke, JS Gujral, ML Bajt - Liver International, 2004 - Wiley Online Library
Liver cell injury and cell death is a prominent feature in all liver disease processes. During
the last 5–10 years, most research activities focused almost exclusively on evaluating …
the last 5–10 years, most research activities focused almost exclusively on evaluating …
NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia
JS Gujral, JA Hinson, A Farhood… - American Journal of …, 2004 - journals.physiology.org
Neutrophils can cause liver injury during endotoxemia through generation of reactive
oxygen species. However, the enzymatic source of the oxidant stress and the nature of the …
oxygen species. However, the enzymatic source of the oxidant stress and the nature of the …
Protection against Fas Receptor–Mediated Apoptosis in Hepatocytes and Nonparenchymal Cells by a Caspase-8 Inhibitor in Vivo: Evidence for a Postmitochondrial …
…, JA Lawson, SL Vonderfecht, JS Gujral… - Toxicological …, 2000 - academic.oup.com
Lymphocytes can kill target cells including hepatocytes during various inflammatory diseases
by Fas receptor–mediated apoptosis. Caspase-8 is activated at the receptor level, thereby …
by Fas receptor–mediated apoptosis. Caspase-8 is activated at the receptor level, thereby …
Reduced oncotic necrosis in fas receptor-deficient C57BL/6J-lprmice after bile duct ligation
JS Gujral, J Liu, A Farhood, H Jaeschke - Hepatology, 2004 - journals.lww.com
Neutrophils aggravate cholestatic liver injury after bile duct ligation (BDL). Recently, it was
suggested that hepatocellular apoptosis might be critical for liver injury in this model. To test …
suggested that hepatocellular apoptosis might be critical for liver injury in this model. To test …
Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats
JS Gujral, A Farhood, H Jaeschke - Toxicology and applied pharmacology, 2003 - Elsevier
The mode of cell death during galactosamine (Gal)-induced liver injury was originally thought
to be oncotic necrosis but recently it was suggested to be apoptosis. Thus, the objective …
to be oncotic necrosis but recently it was suggested to be apoptosis. Thus, the objective …
Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia
RB Dorman, JS Gujral, ML Bajt… - American Journal …, 2005 - journals.physiology.org
… 17 Gujral JS, Hinson JA, Farhood A, and Jaeschke H. NADPH oxidase-derived oxidant
stress is critical for neutrophil cytotoxicity during endotoxemia. Am J Physiol Gastrointest Liver …
stress is critical for neutrophil cytotoxicity during endotoxemia. Am J Physiol Gastrointest Liver …