User profiles for Jayanta Roy Chowdhury
Jayanta Roy-ChowdhuryProfessor of Medicine and Genetics, Albert Einstein College of Medicine Verified email at Einsteinmed.edu Cited by 21670 |
[HTML][HTML] The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
PJ Bosma, JR Chowdhury, C Bakker… - … England Journal of …, 1995 - Mass Medical Soc
Background People with Gilbert's syndrome have mild, chronic unconjugated hyperbilirubinemia
in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, …
in the absence of liver disease or overt hemolysis. Hepatic glucuronidating activity, …
[HTML][HTML] Treatment of the Crigler–Najjar syndrome type I with hepatocyte transplantation
IJ Fox, JR Chowdhury, SS Kaufman… - … England Journal of …, 1998 - Mass Medical Soc
Crigler–Najjar syndrome type I is a recessively inherited disorder characterized by severe
unconjugated hyperbilirubinemia beginning at birth. The syndrome results from an absence of …
unconjugated hyperbilirubinemia beginning at birth. The syndrome results from an absence of …
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence
…, P Louisot, J Magdalou, JR Chowdhury… - Pharmacogenetics …, 1997 - journals.lww.com
This review represents an update of the nomenclature system for the UDP glucuronosyltransferase
gene superfamily, which is based on divergent evolution. Since the previous review …
gene superfamily, which is based on divergent evolution. Since the previous review …
Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man.
…, RPO Elferink, JR Chowdhury, NR Chowdhury… - Journal of Biological …, 1994 - Elsevier
Crigler-Najjar syndrome type I (CN-I) is caused by an inherited absence of UDP-glucuronosyltransferase
activity toward bilirubin (B-UGT), resulting in severe non-hemolytic …
activity toward bilirubin (B-UGT), resulting in severe non-hemolytic …
Genetic lesions of bilirubin uridine‐diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler‐Najjar and Gilbert syndromes: correlation of genotype …
…, G Sharma, JR Chowdhury, NR Chowdhury - Human …, 2000 - Wiley Online Library
Uridine‐diphosphoglucuronate glucuronosyltransferases (UGTs) are a family of enzymes
that conjugate various endogenous and exogenous compounds with glucuronic acid and …
that conjugate various endogenous and exogenous compounds with glucuronic acid and …
Differentiation and transplantation of human embryonic stem cell–derived hepatocytes
BACKGROUND & AIMS: The ability to obtain unlimited numbers of human hepatocytes would
improve the development of cell-based therapies for liver diseases, facilitate the study of …
improve the development of cell-based therapies for liver diseases, facilitate the study of …
Hepatocyte transplantation for the treatment of human disease
SC Strom, JR Chowdhury, IJ Fox - Seminars in liver disease, 1999 - thieme-connect.com
A great deal of work with animal models indicates that hepatocytes transplanted into the
liver or spleen survive, function, and participate in the normal regenerative process. Recent …
liver or spleen survive, function, and participate in the normal regenerative process. Recent …
Hepatocyte transplantation
IJ Fox, J Roy-Chowdhury - Journal of hepatology, 2004 - Elsevier
Transplantation of the whole liver, or a portion of the liver, has been remarkably effective in
the treatment of liver failure and liver-based inherited metabolic diseases. In spite of …
the treatment of liver failure and liver-based inherited metabolic diseases. In spite of …
Glucuronidation and the UDP-glucuronosyltransferases in health and disease
This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …
Improving the techniques for human hepatocyte transplantation: report from a consensus meeting in London
On September 6 and 7, 2009 a meeting was held in London to identify and discuss what are
perceived to be current roadblocks to effective hepatocyte transplantation as it is currently …
perceived to be current roadblocks to effective hepatocyte transplantation as it is currently …