The pregnane X receptor (PXR) has three known major transcript variants resulting from
alternative splicing. The less well characterized variants T2 and T3 are identical to the well …

At the periphery of the olfactory system, the binding of odorants on olfactory receptors (ORs)
is usually thought to be the first level of the perception of smell. However, at this stage, there …

Escherichia coli is an important experimental, medical and industrial cell factory for
recombinant protein production. The inducible lac promoter is one of the most commonly used …

It is generally accepted that the rate of entry into and distribution of drugs and other xenobiotics
within the central nervous system (CNS) depends on the particular anatomy of the brain …

trans-Resveratrol is a polyphenol present in several plant species. Its chemopreventive
properties against several diseases have been largely documented. To validate a model for the …

A large set of xenobiotic-metabolizing enzymes (XMEs), such as the cytochrome P450
monooxygenases (CYPs), esterases and transferases, are highly expressed in mammalian …

Odorant metabolizing enzymes (OMEs) are expressed in the olfactory epithelium (OE)
where they play a significant role in the peripheral olfactory process by catalyzing the fast …

… Jean-Marie Heydel is a Professor in biochemistry and molecular biology and research
deputy of the Pharmacy department at the University Bourgogne Franche-Comté, Dijon, France. …

Glutathione transferases (GSTs) are ubiquitous key enzymes that catalyse the conjugation
of glutathione to xenobiotic compounds in the detoxification process. GSTs have been …

Caffeine (1, 3, 7-trimethylxanthine), an alkaloid produced by plants, has antioxidant and
insecticide properties that can affect metabolism and cognition. In vertebrates, the metabolites …