A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-…
inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-…
[HTML][HTML] Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
…, G Seibel, TG Porter, GP Livi, JL Adams… - Journal of Biological …, 1997 - ASBMB
The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of
p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production …
p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production …
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption …
…, JN Bradbeer, B Votta, JC Lee, JL Adams… - … of Pharmacology and …, 1996 - ASPET
SB 203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4- pyridyl)imidazole], a
selective cytokine suppressive binding protein/p38 kinase inhibitor, was evaluated in several …
selective cytokine suppressive binding protein/p38 kinase inhibitor, was evaluated in several …
Inhibition of p38 MAP kinase as a therapeutic strategy
…, DE Griswold, DC Underwood, BJ Votta, JL Adams - …, 2000 - Elsevier
Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed
dramatically. The key advances include (1) identification of p38 MAP kinase homologs …
dramatically. The key advances include (1) identification of p38 MAP kinase homologs …
[PDF][PDF] Structural basis of inhibitor selectivity in MAP kinases
…, MH Cobb, PR Young, S Abdel-Meguid, JL Adams… - Structure, 1998 - cell.com
Background: The mitogen-activated protein (MAP) kinases are important signaling molecules
that participate in diverse cellular events and are potential targets for intervention in …
that participate in diverse cellular events and are potential targets for intervention in …
Big opportunities for small molecules in immuno-oncology
JL Adams, J Smothers, R Srinivasan… - Nature reviews Drug …, 2015 - nature.com
The regulatory approval of ipilimumab (Yervoy) in 2011 ushered in a new era of cancer
immunotherapies with durable clinical effects. Most of these breakthrough medicines are …
immunotherapies with durable clinical effects. Most of these breakthrough medicines are …
SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung
…, JC Lee, AM Romanic, JL Adams… - … of Physiology-Lung …, 2000 - journals.physiology.org
The effects of a second generation p38 mitogen-activated protein kinase (MAPK) inhibitor,
SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)…
SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)…
p38 mitogen-activated protein kinase inhibitors—mechanisms and therapeutic potentials
…, S Kassis, S Kumar, A Badger, JL Adams - Pharmacology & …, 1999 - Elsevier
The pyridinylimidazole compounds, exemplified by SB 203580, originally were prepared as
inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be …
inflammatory cytokine synthesis inhibitors. Subsequently, the compounds were found to be …
Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
S Kumar, MS Jiang, JL Adams, JC Lee - Biochemical and biophysical …, 1999 - Elsevier
p38 MAPK is a Ser/Thr protein kinase activated by various inflammatory cytokines and a
variety of stress stimuli. It is involved in many physiological processes, including the production …
variety of stress stimuli. It is involved in many physiological processes, including the production …
Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date.
DE Griswold, JL Adams - Medicinal research reviews, 1996 - europepmc.org
While a great deal has been discovered concerning the potential physiological and pathological
role of prostanoids, much is left to be determined. The widespread distribution of both …
role of prostanoids, much is left to be determined. The widespread distribution of both …