Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

…, KG Coleman, SK Loftus, D Zhang, C Cummings, J Gu… - Science, 1997 - science.org
Niemann-Pick type C (NP-C) disease, a fatal neurovisceral disorder, is characterized by
lysosomal accumulation of low density lipoprotein (LDL)–derived cholesterol. By positional …

Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene

SK Loftus, JA Morris, ED Carstea, JZ Gu, C Cummings… - Science, 1997 - science.org
An integrated human-mouse positional candidate approach was used to identify the gene
responsible for the phenotypes observed in a mouse model of Niemann-Pick type C (NP-C) …

Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual‐acting angiotensin receptor—neprilysin inhibitor (ARNi)

J Gu, A Noe, P Chandra, S Al‐Fayoumi… - The Journal of …, 2010 - Wiley Online Library
Angiotensin receptor blockade and neprilysin (NEP) inhibition together offer potential benefits
for the treatment of hypertension and heart failure. LCZ696 is a novel single molecule …

Oncotargets GD2 and GD3 are highly expressed in sarcomas of children, adolescents, and young adults

K Dobrenkov, I Ostrovnaya, J Gu… - Pediatric blood & …, 2016 - Wiley Online Library
Background GD2 and GD3 are the tumor‐associated glycolipid antigens found in a broad
spectrum of human cancers. GD2‐specific antibody is currently a standard of care for high‐risk …

Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy

P Couvert, P Giral, S Dejager, J Gu, T Huby… - 2008 - Future Medicine
Introduction: Marked lowering of low-density-lipoprotein cholesterol (LDL-C) levels (≤50%)
with intensive statin therapy is associated with major reduction in cardiovascular risk, but is …

TROPION-PanTumor01: Dose analysis of the TROP2-directed antibody-drug conjugate (ADC) datopotamab deruxtecan (Dato-DXd, DS-1062) for the treatment (Tx) of …

…, A Petrich, J Greenberg, N Tajima, Y Kawasaki, J Gu… - 2021 - ascopubs.org
9058 Background: Datopotamab deruxtecan (Dato-DXd; DS-1062) is an ADC composed of
a humanized anti-TROP2 IgG1 monoclonal antibody conjugated to a topoisomerase I …

Assessment of clinical palliative care trigger status vs actual needs among critically ill patients and their family members

…, C Naglee, JN Katz, A Frear, EH Pratt, J Gu… - JAMA Network …, 2022 - jamanetwork.com
Importance Palliative care consultations in intensive care units (ICUs) are increasingly prompted
by clinical characteristics associated with mortality or resource utilization. However, it is …

[HTML][HTML] Novel mutations in the gene encoding ATP-binding cassette 1 in four Tangier disease kindreds

…, JM Ordovas, MW Freeman, RH Brown, JZ Gu - Journal of lipid …, 2000 - ASBMB
Tangier disease (TD) is an autosomal co-dominant disorder in which homozygotes have a
marked deficiency of high density lipoprotein (HDL) cholesterol and, in some cases, …

The antiepileptic drug levetiracetam selectively modifies kindling‐induced alterations in gene expression in the temporal lobe of rats

J Gu, BA Lynch, D Anderson, H Klitgaard… - European Journal of …, 2004 - Wiley Online Library
Gene expression profiling by microarrays is a powerful tool for identification of genes that
may encode key proteins involved in molecular mechanisms underlying epileptogenesis. …

TROPION-Lung02: Datopotamab deruxtecan (Dato-DXd) plus pembrolizumab (pembro) with or without platinum chemotherapy (Pt-CT) in advanced non-small cell …

…, M Provencio, A Horiike, E Pan, D Lin, J Gu… - 2023 - ascopubs.org
9004 Background: Despite advances in first-line (1L) immunotherapy ± CT, most patients (pts)
with aNSCLC experience disease progression, necessitating novel strategies. Dato-DXd …