Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues

Y Noguchi, J Wu, R Duncan, J Strohalm… - Japanese Journal of …, 1998 - Wiley Online Library
The objective of this study was to investigate the molecular weight (MW) and time‐dependence
of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in …

Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

T Etrych, L Kovář, J Strohalm, P Chytil, B Říhová… - Journal of controlled …, 2011 - Elsevier
Herein, new biodegradable star polymer–doxorubicin conjugates designed for passive tumor
targeting were investigated, and their synthesis, physico-chemical characterization, drug …

HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity

T Etrych, V Šubr, J Strohalm, M Šírová, B Říhová… - Journal of controlled …, 2012 - Elsevier
The molecular weight and molecular architecture of soluble polymer drug carriers
significantly influence the biodistribution and anti‐tumour activities of their doxorubicin (DOX) …

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

T Etrych, J Strohalm, P Chytil, P Černoch… - European journal of …, 2011 - Elsevier
New biodegradable star polymer–doxorubicin (Dox) conjugates designed for passive tumor
targeting were investigated and the present study described their synthesis, physico-…

Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect

M Kovář, J Strohalm, T Etrych, K Ulbrich… - Bioconjugate …, 2002 - ACS Publications
The aim of this study was to compare the properties and antitumor potential of a novel type
of antibody-targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound …

Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin

K Ulbrich, J Strohalm, J Kopeček - Biomaterials, 1982 - Elsevier
New types of hydrophilic gels based on N-(2-hydroxypropyl)methacrylamide which contain
oligopeptide sequences in the crosslinks were prepared. These gels are enzymatically …

Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA

…, LW Seymour, S Smart, J Strohalm… - Bioconjugate …, 1999 - ACS Publications
Cationic polymer/DNA complexes are widely used for gene delivery, although the influence
of the cationic polymer on the biophysical properties of the resulting complex is poorly …

Anticancer agents coupled to N-(2-hydroxypropyl) methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo

…, IC Hume, P Kopečková, K Ulbrich, J Strohalm… - Journal of controlled …, 1989 - Elsevier
N-(2-Hydroxypropyl)methyocrylamide (HPMA) copolymers were synthesized to contain
adriamycin (ADR) and in certain cases fucosylamine or galactosamine residues. Drug was …

Drug-HPMA-HuIg conjugates effective against human solid cancer

B ŘÍHovÁ, JŘÍ Strohalm, KŘI KubÁČKovÁ… - Polymer Drugs in the …, 2003 - Springer
Conclusion N-(2-hydroxypropyl)methacrylamide copolymer (PHPMA)-bound doxorubicin
conjugated with human Ig as a targeting moiety was used for the first time in the setting of …

Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments

M Strohalm, J Strohalm, F Kaftan, L Krásný… - Analytical …, 2011 - ACS Publications
Traditional tissue-sectioning techniques for histological samples utilize various embedding
media to stabilize the tissue on a sectioning target and to provide a smooth cutting surface. …