Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues
Y Noguchi, J Wu, R Duncan, J Strohalm… - Japanese Journal of …, 1998 - Wiley Online Library
The objective of this study was to investigate the molecular weight (MW) and time‐dependence
of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in …
of the phenomenon termed “the enhanced permeability and retention”(EPR) effect in …
Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy
Herein, new biodegradable star polymer–doxorubicin conjugates designed for passive tumor
targeting were investigated, and their synthesis, physico-chemical characterization, drug …
targeting were investigated, and their synthesis, physico-chemical characterization, drug …
HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity
T Etrych, V Šubr, J Strohalm, M Šírová, B Říhová… - Journal of controlled …, 2012 - Elsevier
The molecular weight and molecular architecture of soluble polymer drug carriers
significantly influence the biodistribution and anti‐tumour activities of their doxorubicin (DOX) …
significantly influence the biodistribution and anti‐tumour activities of their doxorubicin (DOX) …
Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting
New biodegradable star polymer–doxorubicin (Dox) conjugates designed for passive tumor
targeting were investigated and the present study described their synthesis, physico-…
targeting were investigated and the present study described their synthesis, physico-…
Star structure of antibody-targeted HPMA copolymer-bound doxorubicin: a novel type of polymeric conjugate for targeted drug delivery with potent antitumor effect
M Kovář, J Strohalm, T Etrych, K Ulbrich… - Bioconjugate …, 2002 - ACS Publications
The aim of this study was to compare the properties and antitumor potential of a novel type
of antibody-targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound …
of antibody-targeted N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound …
Polymers containing enzymatically degradable bonds. VI. Hydrophilic gels cleavable by chymotrypsin
K Ulbrich, J Strohalm, J Kopeček - Biomaterials, 1982 - Elsevier
New types of hydrophilic gels based on N-(2-hydroxypropyl)methacrylamide which contain
oligopeptide sequences in the crosslinks were prepared. These gels are enzymatically …
oligopeptide sequences in the crosslinks were prepared. These gels are enzymatically …
Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA
…, LW Seymour, S Smart, J Strohalm… - Bioconjugate …, 1999 - ACS Publications
Cationic polymer/DNA complexes are widely used for gene delivery, although the influence
of the cationic polymer on the biophysical properties of the resulting complex is poorly …
of the cationic polymer on the biophysical properties of the resulting complex is poorly …
Anticancer agents coupled to N-(2-hydroxypropyl) methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo
…, IC Hume, P Kopečková, K Ulbrich, J Strohalm… - Journal of controlled …, 1989 - Elsevier
N-(2-Hydroxypropyl)methyocrylamide (HPMA) copolymers were synthesized to contain
adriamycin (ADR) and in certain cases fucosylamine or galactosamine residues. Drug was …
adriamycin (ADR) and in certain cases fucosylamine or galactosamine residues. Drug was …
Drug-HPMA-HuIg conjugates effective against human solid cancer
B ŘÍHovÁ, JŘÍ Strohalm, KŘI KubÁČKovÁ… - Polymer Drugs in the …, 2003 - Springer
Conclusion N-(2-hydroxypropyl)methacrylamide copolymer (PHPMA)-bound doxorubicin
conjugated with human Ig as a targeting moiety was used for the first time in the setting of …
conjugated with human Ig as a targeting moiety was used for the first time in the setting of …
Poly[N-(2-hydroxypropyl)methacrylamide]-Based Tissue-Embedding Medium Compatible with MALDI Mass Spectrometry Imaging Experiments
M Strohalm, J Strohalm, F Kaftan, L Krásný… - Analytical …, 2011 - ACS Publications
Traditional tissue-sectioning techniques for histological samples utilize various embedding
media to stabilize the tissue on a sectioning target and to provide a smooth cutting surface. …
media to stabilize the tissue on a sectioning target and to provide a smooth cutting surface. …