We employ the CRISPR-Cas system of Streptococcus pyogenes as programmable RNA-guided
endonucleases (RGENs) to cleave DNA in a targeted manner for genome editing in …

Editing plant genomes without introducing foreign DNA into cells may alleviate regulatory
concerns related to genetically modified plants. We transfected preassembled complexes of …

Genome editing has potential for the targeted correction of germline mutations. Here we
describe the correction of the heterozygous MYBPC3 mutation in human preimplantation …

In most operating systems which are customized for disk-based storage system, the
replacement algorithm concerns only the number of memory hits. However, flash memory has …

Programmable nucleases — including zinc-finger nucleases (ZFNs), transcription activator-like
effector nucleases (TALENs) and RNA-guided engineered nucleases (RGENs) derived …

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell
Research and Clinical Translation in order to address advances in stem cell science and …

Biodiesel production is undergoing rapid technological reforms in industries and academia.
This has become more obvious and relevant since the recent increase in the petroleum …

Transcription activator–like (TAL) effector nucleases (TALENs) can be readily engineered to
bind specific genomic loci, enabling the introduction of precise genetic modifications such …

RNA-guided engineered nucleases (RGENs) derived from the prokaryotic adaptive immune
system known as CRISPR (clustered, regularly interspaced, short palindromic repeat)/Cas (…

Programmable clustered regularly interspaced short palindromic repeats (CRISPR) Cpf1
endonucleases are single-RNA-guided (crRNA) enzymes that recognize thymidine-rich …