[HTML][HTML] Synergistic effect of polystyrene nanoplastics and contaminants on the promotion of insulin fibrillation

C Li, Y Ma, X Liu, R Huang, R Su, W Qi, J Che… - … and Environmental Safety, 2021 - Elsevier
Nanoplastics (NPs) are becoming an emerging pollutant of global concern. A potential risk
of NPs is that they can serve as carriers and synergistically function with other contaminants …

Zwitterionic peptide enhances protein-resistant performance of hyaluronic acid-modified surfaces

H Ye, J Che, R Huang, W Qi, Z He, R Su - Langmuir, 2020 - ACS Publications
A convenient and efficient approach for the surface modification of antifouling materials is
highly desirable in numerous applications like affinity-based biosensors. Herein, we fabricated …

[HTML][HTML] Design, synthesis, biological evaluation, and molecular dynamics simulation of influenza polymerase PB2 inhibitors

X Li, Y Xu, W Li, J Che, X Zhao, R Cao, X Li, S Li - Molecules, 2023 - mdpi.com
The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified
as a promising target for the treatment of influenza. To expand the chemical space of the …

A ratiometric hypochlorite-specific nanoprobe constructed by rationally designed AIE luminogen for fluorescence imaging of alcoholic liver disease

W Liang, G Nie, J Che, Z Zhang, D Chen… - Sensors and Actuators B …, 2023 - Elsevier
There is a lack of effective and friendly diagnostic technique for alcoholic liver disease (ALD).
Fluorescence imaging, which has been widely applied in disease diagnostic ascribed to …

AIE fluorescent probes for monitoring cell membrane fluidity/lipid droplet change during alcoholic liver disease

G Nie, J Che, Y Feng, W Liang, D Chen, H Wang - Dyes and Pigments, 2023 - Elsevier
Alcoholic liver disease (ALD) has attracted widespread attention because of the ever-increasing
alcohol consumption and high morbidity. However, there is still no effective detection …

[HTML][HTML] Novel αO-conotoxin GeXIVA [1, 2] Nonaddictive Analgesic with Pharmacokinetic Modelling-Based Mechanistic Assessment

X Zhu, M Yuan, H Wang, D Zhangsun, G Yu, J Che… - Pharmaceutics, 2022 - mdpi.com
αO-conotoxin GeXIVA[1,2] was isolated in our laboratory from Conus generalis, a snail
native to the South China Sea, and is a novel, nonaddictive, intramuscularly administered …

[HTML][HTML] UPLC-MS/MS method for Icariin and metabolites in whole blood of C57 mice: development, validation, and pharmacokinetics study

W Liu, X Li, N Li, Z Mi, N Li, J Che - Frontiers in Pharmacology, 2023 - frontiersin.org
Icariin, a Chinese medicinal herb with significant effects on Alzheimer’s disease, lacks
pharmacokinetic data in mice. To address this, a UPLC-MS/MS method was developed and …

Single-and multiple-dose pharmacokinetics of exendin-4 in rhesus monkeys

G Ai, Z Chen, C Shan, J Che, Y Hou… - International journal of …, 2008 - Elsevier
A radioimmunoassay (RIA) for the measurement of exendin-4 concentration in rhesus
monkeys serum was developed and validated. The radioimmunoassay described here was …

Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracen in human plasma

J Che, Q Meng, Z Chen, C San, Y Hou… - Journal of pharmaceutical …, 2007 - Elsevier
A sensitive method has been developed and validated, using LC/ESI-MS/MS, for simultaneous
quantitation of flupentixol and melitracen—antidepressant drugs, in human plasma. The …

[HTML][HTML] Tumor endothelium marker-8 based decoys exhibit superiority over capillary morphogenesis protein-2 based decoys as anthrax toxin inhibitors

C Cai, J Che, L Xu, Q Guo, Y Kong, L Fu, J Xu… - PLoS …, 2011 - journals.plos.org
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. The toxin consists
of three protein subunits: protective antigen (PA), lethal factor, and edema factor. Inhibition …