High-activity p-glycoprotein, multidrug resistance protein 2, and breast cancer resistance protein membrane vesicles prepared from transiently transfected human …

JE Karlsson, C Heddle, A Rozkov… - Drug metabolism and …, 2010 - ASPET
Membrane-bound transporter proteins play an important role in the efflux of drugs from cells
and can significantly influence the pharmacokinetics of drug molecules. This study …

Investigation of the involvement of P-glycoprotein and multidrug resistance-associated protein 2 in the efflux of ximelagatran and its metabolites by using short hairpin …

M Darnell, JE Karlsson, A Owen, IJ Hidalgo, J Li… - Drug metabolism and …, 2010 - ASPET
Liver and bile secretion can be an important first-pass and clearance route for drug
compounds and also the site of several drug-drug interactions. In the clinical program for …

[HTML][HTML] Sustainable Timber Transport—Economic Aspects of Aerodynamic Reconfiguration

E Johannes, P Ekman, M Huge-Brodin, M Karlsson - Sustainability, 2018 - mdpi.com
There is a need to reduce fuel consumption, and thereby reduce CO 2 -emissions in all
parts of the transport sector. It is also well known that aerodynamic resistance affects the fuel …

[HTML][HTML] The effects of pregnenolone 16α-carbonitrile dosing on digoxin pharmacokinetics and intestinal absorption in the rat

…, IS Haslam, BM Fihn, C Hilgendorf, JE Karlsson… - Pharmaceutics, 2010 - mdpi.com
The effect of Pgp induction in rats by pregnenolone 16α-carbonitrile (PCN) (3 days, 35 mg/kg/d,
po) on digoxin pharmacokinetics and intestinal transport has been assessed. After …

[PDF][PDF] Investigation of the involvement of P-gp and MRP2 in the efflux of ximelagatran and its metabolites by using short hairpin RNA knockdown in Caco-2 cells

M Darnell, JE Karlsson, A Owen, J Li… - Drug Metabolism and …, 2009 - researchgate.net
Liver and bile secretion can be an important first pass and clearance route for drug compounds
and also the site of several drug-drug interactions (DDIs). In the clinical program for …

Efficacy and safety of autologous dendritic cell–based immunotherapy, docetaxel, and prednisone vs placebo in patients with metastatic castration-resistant prostate …

…, B Mellado, D Castellano, J Puente, ET Karlsson… - JAMA …, 2022 - jamanetwork.com
Importance DCVAC/PCa is an active cellular immunotherapy designed to initiate an immune
response against prostate cancer. Objective To evaluate the efficacy and safety of DCVAC/…

Internet administered guided self-help versus individualized e-mail therapy: A randomized trial of two versions of CBT for major depression

…, J Lenndin, J Bjärehed, M Carlsson, J Karlsson… - Behaviour research and …, 2010 - Elsevier
Internet-delivered psychological treatment of major depression has been investigated in
several trials, but the role of personalized treatment is less investigated. Studies suggest that …

[PDF][PDF] Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout …

LS Lindström, E Karlsson, UM Wilking, U Johansson… - J Clin …, 2012 - researchgate.net
… Wilking, Ulla Johansson, Johan Hartman, Elisabet Kerstin Lidbrink, Thomas Hatschek,
Lambert Skoog Data analysis and interpretation: Linda Sofie Lindström, Eva Karlsson …

Variable turbine geometry on SI engines

J Andersen, E Karlsson, A Gawell - 2006 - sae.org
Six closely matched turbochargers with variable geometry turbines, VGT, were benchmarked
and investigated on a 2 litre spark ignited, SI, engine in order to evaluate their on-engine …

[HTML][HTML] Effects of interactive patient smartphone support app on drug adherence and lifestyle changes in myocardial infarction patients: A randomized study

…, J Alfredsson, PA Albertsson, JE Karlsson… - American heart …, 2016 - Elsevier
Background Patients with myocardial infarction (MI) seldom reach recommended targets for
secondary prevention. This study evaluated a smartphone application (“app”) aimed at …