▪ Abstract This review describes the three mammalian glutathione transferase (GST) families,
namely cytosolic, mitochondrial, and microsomal GST, the latter now designated MAPEG. …

The glutathione S-transferases (GST) represent a major group of detoxification enzymes. All
eukaryotic species possess multiple cytosolic and membrane-bound GST isoenzymes, each …

Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to
as oxidative stress, respresents a potentially toxic insult which if not counteracted will lead to …

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2, also called Nfe2l2) is a transcription
factor that regulates the cellular redox status. Nrf2 is controlled through a complex …

The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic
degradation of ubiquitinated targets, is up-regulated by various stressors. Induction of the …

Two supergene families encode proteins with glutathione S-transferase (GST) activity: the
family of soluble enzymes comprises at least 16 genes; the separate family of microsomal …

Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of …

Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular
adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1)…