Two sublines of a breast epithelial cell culture, MCF-10, derived from human fibrocystic
mammary tissue exhibit immortality after extended cultivation in low calcium concentrations (0.03…

It has been demonstrated that in humans certain factors such as early menarche, late
pregnancy, and nulliparity are associated with a higher risk of developing breast cancer, while …

We have learned through the study of human breast cancer that this disease is the result of
a combination of factors, among them external factors such as ionizing radiation, diet, …

Mechanisms underlying global changes in gene expression during tumour progression are
poorly understood. SATB1 is a genome organizer that tethers multiple genomic loci and …

Breast cancer, the most frequent spontaneous malignancy diagnosed in women in the western
world, is continuously increasing in incidence in industrialized nations. Although breast …

Epidemiological, clinical, and experimental data indicate that the risk of developing breast
cancer is strongly dependent on the ovary and on endocrine conditions modulated by ovarian …

Breast cancer, the most frequent spontaneousmalignancy diagnosed in women in the
Western world, isa classical model of hormone dependent malignancy. Thereis substantial …

NIH sponsored a meeting of medical and veterinary pathologists with mammary gland
expertise in Annapolis in March 1999. Rapid development of mouse mammary models has …

Exposure to estrogens is associated with increased risk of breast and other types of human
cancer. Estrogens are converted to metabolites, particularly the catechol estrogen-3,4-…

The human breast undergoes a complete series of changes from intrauterine life to senescence.
These changes can be divided into two distinct phases; the developmental phase and …