Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other
inflammatory processes, and these cells can be activated through their T cell antigen …

Affinity-optimized T cell receptors can enhance the potency of adoptive T cell therapy.
Afamitresgene autoleucel (afami-cel) is a human leukocyte antigen-restricted autologous T cell …

… Author links open overlay panel Ying Wu BSc a , Joseph P. Sanderson BSc a , John Farrell
BSc a , Nicola S. Drummond PhD a , Anita Hanson BSc a , Elizabeth Bowkett BSc b , Neil …

Different signals in addition to the antigenic signal are required to initiate an immunological
reaction. In the context of sulfamethoxazole allergy, the Ag is thought to be derived from its …

Robust preclinical testing is essential to predict clinical safety and efficacy and provide data
to determine safe dose for first-in-man studies. There are a growing number of examples …

A substantial obstacle to the success of adoptive T cell-based cancer immunotherapy is the
sub-optimal affinity of T-cell receptors (TCRs) for most tumor antigens. Genetically …

Circulating T-cells that have passed thymic selection generally bear T-cell receptors (TCRs)
with sub-optimal affinity for cancer-associated antigens, resulting in a limited ability to detect …

Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic
options. Alpha‐fetoprotein (AFP) is often expressed at high levels in HCC and is an …

β-Lactam antibiotics provide the cornerstone of treatment for respiratory exacerbations in
patients with cystic fibrosis. Unfortunately, approximately 20% of patients develop multiple …

Background ADP-A2M10 specific peptide enhanced affinity receptor (SPEAR) T cells (ADP-A2M10)
are genetically engineered autologous T cells that express a high-affinity melanoma-…