Background. Elevated immune activation persists during treated human immunodeficiency
virus (HIV) infection and is associated with blunted CD4 recovery and premature mortality, …

Inflammation has increasingly been recognized as a critical component influencing tumor
growth. Recent reports have revealed conflicting evidence for the role of Toll-like receptors (…

This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key
SAR and critical binding elements are discussed. Some of the more advanced analogues …

Purpose The Aurora family of serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C)
plays a key role in cells orderly progression through mitosis. Elevated expression levels of …

Background A new method for detecting circulating Ewing sarcoma cells using flow cytometry
is described. This strategy exploits the nearly universal expression of CD99 and the lack of …

Carfilzomib (CFZ) is a second-generation proteasome inhibitor that is Food and Drug
Administration and European Commission approved for the treatment of relapsed or refractory …

Oprozomib is an oral proteasome inhibitor currently under investigation in patients with
hematologic malignancies or solid tumors. Oprozomib elicits potent pharmacological actions by …

METHODS Subcutanous tumor models established by implanting transgenic adenocarcinoma
of the mouse prostate (TRAMP) cell lines in C57Bl6 wild-type mice and in mice deficient …

Shakespeare's effect on America's intellectual and artistic life has been much discussed, but
what role does he play on the American popular stage? This study changes our …

Question Presented: Is 18 USC § 48 facially invalid under the Free Speech Clause of the
First Amendment?(18 USC § 48 prohibits the knowing creation, sale, or possession of a …