Modulation of the activity of ABC transporters (P-glycoprotein, MRP2, BCRP) by flavonoids and drug response

…, M Pérez, G Mendoza, JG Prieto, G Merino - Journal of …, 2010 - Elsevier
The present article aims to review the up-to-date information on the most recent studies of
the interaction of flavonoids with ABC transporters, in particular the drug pharmacokinetic …

Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion

…, MM Pulido, AJ Molina, AH Schinkel, JG Prieto - Drug Metabolism and …, 2006 - ASPET
The breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette drug efflux
transporter that extrudes xenotoxins from cells in intestine, liver, mammary gland, and other …

Protective effects of Panax ginseng on muscle injury and inflammation after eccentric exercise

ACC De Oliveira, AC Perez, G Merino, JG Prieto… - … and Physiology Part C …, 2001 - Elsevier
Eccentric muscle contraction causes fibre injury associated with disruption of the myofibrillar
cytoskeleton. The medicinal plant Panax ginseng CA Meyer, known for its therapeutic …

Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep

…, G Merino, G Mendoza, JG Prieto… - Journal of veterinary …, 2006 - Wiley Online Library
The ATP‐binding cassette (ABC) transporter breast cancer resistance protein (BCRP)/ABCG2
is a high‐capacity efflux transporter with wide substrate specificity located in apical …

Fluoroquinolone efflux mediated by ABC transporters

…, JG Prieto, AJ Molina, R Real, G Merino - Journal of …, 2008 - Elsevier
Quinolones and fluoroquinolones are broad spectrum bactericidal drugs, which are widely
used in both human and veterinary medicine. These drugs can quite easily enter cells and …

Inhibitory effects of different antioxidants on hyaluronan depolymerization

…, G Merino, R Real, P Fernandes, JG Prieto - Carbohydrate …, 2007 - Elsevier
Hyaluronan (HA) was depolymerized by hydroxyl radicals generated from hydrogen
peroxide and cupric ions. Inhibition of HA degradation by four well-known antioxidants was …

Bioavailability of the glucuronide and sulfate conjugates of genistein and daidzein in breast cancer resistance protein 1 knockout mice

…, F Vallejo, B Barrera, G Merino, JG Prieto… - Drug metabolism and …, 2011 - ASPET
The dietary polyphenols genistein and daidzein are potent effectors of biological processes.
The plasma profile of both isoflavones is governed by the presence of phase II conjugates, …

Apoptosis and nitric oxide in an experimental model of osteoarthritis in rabbit after hyaluronic acid treatment

L Díaz‐Gallego, JG Prieto, P Coronel… - Journal of …, 2005 - Wiley Online Library
Objective: this study determine the effect of hyaluronic acid on chondrocyte apoptosis, as
well as variations in nitric oxide levels in an experimental model of osteoarthritis elicited …

Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C

…, R Real, JG Prieto, AI Álvarez, G Merino - European journal of …, 2010 - Elsevier
Breast Cancer Resistance Protein (ABCG2/BCRP) is an ATP-binding cassette transporter
expressed in absorptive and excretory organs whose main physiological role is protection of …

Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: effect on plasma and milk levels of danofloxacin in sheep

M Perez, JA Otero, B Barrera, JG Prieto, G Merino… - The Veterinary …, 2013 - Elsevier
Danofloxacin is a synthetic fluoroquinolone antibacterial agent and a substrate for ATP-binding
cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP). This protein …