To investigate the pharmacokinetic interaction between cyclosporin A (CsA) and docosahexaenoic
acid (DHA) in vivo, 5 mg/kg CsA was orally or intravenously coadministered with …

According to International Conference on Harmonization guidelines, each drug in
development for administration to women of child-bearing potential must be tested for possible …

In order to bridge the gap of action of dl-sotalol between the human ether-a-go-go-related
gene (hERG) K + channel inhibition in vitro and QT-interval prolongation in vivo, its …

Drug-induced hepatotoxicity is a common reason for discontinuing the development of
candidate clinical drugs. In the present study, we investigated the utility of three-dimensionally …

In primary culture of mouse cerebellar granule cells, the brain-derived neurotrophic factor (BDNF)
gene is activated in an activity-dependent manner, accompanying Ca 2+ influx into …

Dogs have been widely used to study the oral absorption of a drug in drug discovery. However,
there has been no quantitative validation of using dogs to predict the fraction of oral dose …

To identify an orally available drug candidate, a series of 3-benzoylaminophenylacetic acids
were synthesized and evaluated as prostaglandin D 2 (PGD 2 ) receptor antagonists. Some …

Somatostatin receptors are members of G-protein coupled receptor superfamily. Receptors
can be classified into five subtypes, SSTR1 to 5. The highly potent and orally active SSTR2 …

Cardiovascular effects of a highly selective prostaglandin E 2 type 4 (EP 4 ) receptor agonist
ONO-AE1-329 were assessed with the halothane-anesthetized dogs (n=6). ONO-AE1-329 …

Cardiac effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 were assessed in
the halothane-anesthetized dogs under the monitoring of left ventricular pressure-volume …