The characterization of micro‐organisms by matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry

KJ Welham, MA Domin, DE Scannell… - Rapid …, 1998 - Wiley Online Library
A variety of gram‐positive and gram‐negative intact bacterial cells have been analysed by
matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) and shown to …

Characterization of fungal spores by laser desorption/ionization time‐of‐flight mass spectrometry

KJ Welham, MA Domin, K Johnson… - Rapid …, 2000 - Wiley Online Library
A considerable volume of research has now been completed on the application of matrix‐assisted
laser desorption/ionization mass spectrometry (MALDI‐MS) to the analysis of bacteria; …

Cancer proteomics and its application to discovery of therapy response markers in human cancer

L Smith, MJ Lind, KJ Welham, L Cawkwell… - Cancer, 2006 - Wiley Online Library
The administration of chemotherapy either alone or in combination with radiotherapy is an
important factor in reducing the mortality and morbidity of cancer patients. Resistance to both …

Proteomic identification of putative biomarkers of radiotherapy resistance: a possible role for the 26S proteasome?

…, O Qutob, MB Watson, AW Beavis, D Potts, KJ Welham… - Neoplasia, 2009 - Elsevier
PURPOSE: We aimed to identify putative predictive protein biomarkers of radioresistance.
EXPERIMENTAL DESIGN: Three breast cancer cell lines (MCF7, MDA-MB-231, and T47D) …

The proteomic analysis of cisplatin resistance in breast cancer cells.

L Smith, KJ Welham, MB Watson, PJ Drew… - Oncology …, 2007 - europepmc.org
Resistance to cisplatin represents a major obstacle in the effective management of many
cancers, including metastatic breast cancer. We aimed to gain further understanding of the …

The effect of solvent and matrix combinations on the analysis of bacteria by matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry

MA Domin, KJ Welham… - Rapid Communications in …, 1999 - Wiley Online Library
The ability to rapidly identify the taxonomic class of the wide variety of microorganisms
involved in human and animal disease is becoming increasingly important, especially with the …

[HTML][HTML] Optimization of pH as a strategy to improve enzymatic saccharification of wheat straw for enhancing bioethanol production

…, JO Abdulsattar, GM Greenway, KJ Welham… - Journal of Analytical …, 2020 - Springer
In this work, wheat straw (WS) was used as a lignocellulosic substrate to investigate the
influence of pH on enzymatic saccharification. The optimum enzymatic hydrolysis occurred at pH …

Proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia reveals a possible role for kininogen

E Kashuba, GL Eagle, J Bailey, P Evans, KJ Welham… - Journal of …, 2013 - Elsevier
CLL is an incurable disease with variable prognosis. The hyper reactivity of the B-cell receptor
(BCR) to unknown antigen ligation plays a pivotal role in CLL-cell survival. We aimed to …

Identification of cytochrome P450 enzymes in human colorectal metastases and the surrounding liver: a proteomic approach

…, BJ Fuller, BR Davidson, J Hewes, KJ Welham… - European journal of …, 2004 - Elsevier
We describe the direct identification of multiple cytochrome P450 (CYP) enzymes in healthy
and cancerous tissue. CYPs in human liver colorectal metastases were compared with those …

Quantitative analysis of the major constituents of St John's wort with HPLC‐ESI‐MS

…, M Heinrich, D Ashton, KJ Welham… - Journal of pharmacy …, 2005 - Wiley Online Library
A method was developed to profile the major constituents of St John's wort extracts using
highperformance liquid chromatography‐electrospray mass spectrometry (HPLC‐ESI‐MS). …