User profiles for K.-Olaf Boernsen

KO Börnsen

Other name: K. Olaf Boernsen
Verified email at fhnw.ch
Cited by 1742

Pharmacokinetics, distribution, metabolism, and excretion of deferasirox and its iron complex in rats

…, H Nick, J Schneider, KO Boernsen… - Drug metabolism and …, 2008 - ASPET
Deferasirox (Exjade, ICL670, CGP72670) is an iron-chelating drug for po treatment of
transfusional iron overload in patients with β-thalassemia or sickle cell disease. The …

Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma

KO Boernsen, S Gatzek, G Imbert - Analytical Chemistry, 2005 - ACS Publications
Liquid chromatography−mass spectrometry (LC−MS) is a common method for profiling
biological samples in metabolomics. However, LC−MS data of metabolomic studies are often …

Primary structure and function of novel O-glycosylated hirudins from the leech Hirudinaria manillensis

V Steiner, R Knecht, KO Börnsen, E Gassmann… - Biochemistry, 1992 - ACS Publications
Revised Manuscript Received December 3, 1991 abstract: Hirudin from the leech Hirudo
medicinalis is a most powerful anticoagulant, and many isoforms have been described. In …

Ion exchange and purification of carbohydrates on a Nafion® membrane as a new sample pretreatment for matrix‐assisted laser desorption/ionization mass …

KO Börnsen, MD Mohr… - Rapid communications in …, 1995 - Wiley Online Library
A Nafion membrane was tested as a new tool for a fast and easy sample pretreatment for
matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) measurements. …

[HTML][HTML] Evaluation of electrolyte element composition in human tissue by laser-induced breakdown spectroscopy (LIBS)

P Winnand, KO Boernsen, G Bodurov, M Lammert… - Scientific Reports, 2022 - nature.com
Laser-induced breakdown spectroscopy (LIBS) enables the direct measurement of cell
electrolyte concentrations. The utility of LIBS spectra in biomarker studies is limited because …

Matrix-assisted laser desorption and ionization as a mass spectrometric tool for the analysis of poly [(R)-3-hydroxybutanoates]. Comparison with gel permeation …

…, HM Mueller, D Seebach, KO Boernsen… - …, 1993 - ACS Publications
Mass spectrometric analysis of oligomers derived frompoly [(fi)-3-hydroxybutanoate](PHB),
containing up to 96 monomer units, showed that molecules of this polymer with m< 10 000 …

[HTML][HTML] The role of potassium in depth profiling of the tumor border in bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS): a pilot study

P Winnand, KO Boernsen, M Ooms, M Heitzer… - Journal of Cancer …, 2023 - Springer
Purpose Microscopic tumor spread beyond the macroscopically visible tumor mass in bone
represents a major risk in surgical oncology, where the spatial complexity of bony resection …

Influence of salts, buffers, detergents, solvents, and matrices on MALDI-MS protein analysis in complex mixtures

KO Börnsen - Mass Spectrometry of Proteins and Peptides: Mass …, 2000 - Springer
Matrix-assisted laser desorption/ionization mass spectrometry, (MALDI-MS) was initially
used to analyze pure peptide and protein solutions ( 1 – 3 ). Later. MALDI was applied to …

Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus

KO Boernsen, W Egge‐Jacobsen… - Journal of mass …, 2007 - Wiley Online Library
Assessment and validation of the MS/MS fragmentation patterns of the macrolide
immunosuppressant everolimus - Boernsen - 2007 - Journal of Mass Spectrometry - Wiley Online …

Use of a microplate scintillation counter as a radioactivity detector for miniaturized separation techniques in drug metabolism

KO Boernsen, JM Floeckher, GJM Bruin - Analytical chemistry, 2000 - ACS Publications
In miniaturized separation techniques, such as capillary electrophoresis (CE) or capillary
liquid chromatography (LC), conventional on-line radioactivity detection of labeled compounds …