CD4 + regulatory T cells (T reg cells) that produce interleukin 10 (IL-10) are important contributors
to immune homeostasis. We generated mice with a 'dual-reporter' system of the genes …

A hallmark of adaptive immunity is the generation of memory T cells that confer long-lived,
antigen-specific protection against repeat challenges by pathogens 1 , 2 , 3 , 4 , 5 . …

Chromatin dynamics that regulate Ifng gene expression are incompletely understood. By using
cross-species comparative sequence analyses, we have identified conserved noncoding …

MiT family translocation renal cell carcinoma (MiT-RCC) harbors translocations involving the
TFE3 or TFEB genes. RCC with TFEB amplification is also identified and is associated with …

BACKGROUND In the era of personalized medicine, requests for molecular testing of specimens
obtained with minimally invasive procedures such as fine‐needle aspiration have been …

Streptozotocin has been widely used to create animal models of diabetes. Structurally,
streptozotocin resembles N-acetylglucosamine, with a nitrosourea group corresponding to the …

Interleukin (IL)-22 is central to immune defense at barrier sites. We examined the contributions
of innate lymphoid cell (ILC) and T cell-derived IL-22 during Citrobacter rodentium (C.r) …

Objectives To compare the effects of two methods of formalin-fixed paraffin-embedded (FFPE)
tissue harvesting on DNA quality and next-generation sequencing (NGS) quality metrics. …

Differentiation-dependent regulation of the Ifng cytokine gene locus in T helper (Th) cells has
emerged as an excellent model for functional study of distal elements that control lineage-…

Four unrelated patients having an unusual clinical phenotype, including multiple peripheral
nerve sheath tumors, are reported. Their clinical features were not typical of any known …