Transport function, regulation, and biology of human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4)
M Kobayashi, K Narumi, A Furugen, K Iseki - Pharmacology & Therapeutics, 2021 - Elsevier
Human monocarboxylate transporter 1 (hMCT1) and 4 (hMCT4) are involved in the proton-dependent
transport of monocarboxylates such as L-lactate, which play an essential role in …
transport of monocarboxylates such as L-lactate, which play an essential role in …
Effect of diclofenac on SLC16A3/MCT4 by the Caco-2 cell line
…, Y Futagi, M Ideno, M Kobayashi, K Narumi… - Drug Metabolism and …, 2016 - Elsevier
In the present study, we demonstrated that monocarboxylate transporter 4 (MCT4) is
functionally expressed in Caco-2 cells. We studied the effects of 4 nonsteroidal anti-inflammatory …
functionally expressed in Caco-2 cells. We studied the effects of 4 nonsteroidal anti-inflammatory …
Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation
…, M Kobayashi, K Kuwayama, K Narumi… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Background A high intake of fructose increases the risk for hyperuricemia. It has been reported
that long-term fructose consumption suppressed renal uric acid excretion and increased …
that long-term fructose consumption suppressed renal uric acid excretion and increased …
Identification of a selective inhibitor of human monocarboxylate transporter 4
Y Futagi, M Kobayashi, K Narumi, A Furugen… - … and biophysical research …, 2018 - Elsevier
The human monocarboxylate transporters (hMCTs/SLC16As) mediate the uptake of various
monocarboxylates. Several isoforms of hMCTs are expressed in cancerous tissue as well as …
monocarboxylates. Several isoforms of hMCTs are expressed in cancerous tissue as well as …
Association between risk of myopathy and cholesterol-lowering effect: a comparison of all statins
M Kobayashi, I Chisaki, K Narumi, K Hidaka, T Kagawa… - Life sciences, 2008 - Elsevier
In the present study, we examined the mechanisms underlying the cytotoxicity of pitavastatin,
a new statin, and we compared the in vitro potencies of muscle cytotoxicity using a …
a new statin, and we compared the in vitro potencies of muscle cytotoxicity using a …
Effects of proton pump inhibitors and famotidine on elimination of plasma methotrexate: evaluation of drug–drug interactions mediated by organic anion transporter 3
K Narumi, Y Sato, M Kobayashi… - … & drug disposition, 2017 - Wiley Online Library
Methotrexate (MTX) is an antifolate agent used in the treatment of numerous types of cancer,
and eliminated by active tubular secretion via organic anion transporter 3 (OAT3). Gastric …
and eliminated by active tubular secretion via organic anion transporter 3 (OAT3). Gastric …
Magnesium attenuates cisplatin-induced nephrotoxicity by regulating the expression of renal transporters
Y Saito, K Okamoto, M Kobayashi, K Narumi… - European Journal of …, 2017 - Elsevier
Cisplatin (CDDP)-induced nephrotoxicity (CIN) is one of the most serious toxicities caused
by this potent antitumor agent. It has been reported that Mg premedication attenuates CIN in …
by this potent antitumor agent. It has been reported that Mg premedication attenuates CIN in …
Regorafenib is transported by the organic anion transporter 1B1 and the multidrug resistance protein 2
H Ohya, Y Shibayama, J Ogura, K Narumi… - Biological and …, 2015 - jstage.jst.go.jp
Regorafenib is a small molecule inhibitor of tyrosine kinases, and has been shown to improve
the outcomes of patients with advanced colorectal cancer and advanced gastrointestinal …
the outcomes of patients with advanced colorectal cancer and advanced gastrointestinal …
Anticancer effects of non-steroidal anti-inflammatory drugs against cancer cells and cancer stem cells
K Okamoto, Y Saito, K Narumi, A Furugen, K Iseki… - Toxicology in Vitro, 2021 - Elsevier
Certain non-steroidal anti-inflammatory drugs (NSAIDs) are known to have anticancer effects.
However, it is unclear whether all NSAIDs have anticancer effects, and thus far, very few …
However, it is unclear whether all NSAIDs have anticancer effects, and thus far, very few …
Quantification of eight benzodiazepines in human breastmilk and plasma by liquid-liquid extraction and liquid-chromatography tandem mass spectrometry: application …
…, M Kobayashi, T Umazume, K Narumi… - … of pharmaceutical and …, 2019 - Elsevier
Breastfeeding is strongly encouraged for infant and maternal health. Benzodiazepines (BZDs)
are widely prescribed drugs for symptoms, such as anxiety and insomnia, which many …
are widely prescribed drugs for symptoms, such as anxiety and insomnia, which many …